Dual Catalytic Enantioconvergent Carbamoylation of Aziridines

Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations....

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Detalles Bibliográficos
Autores: Zhang, Liangliang, Liu, Huilin, Santiago, Tomás G., Martin, Ruben
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/488974
Acceso en línea:http://hdl.handle.net/2072/488974
https://doi.org/10.1021/jacs.5c15873
Access Level:acceso abierto
Palabra clave:Química
54
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spelling Dual Catalytic Enantioconvergent Carbamoylation of AziridinesZhang, LiangliangLiu, HuilinSantiago, Tomás G.Martin, RubenQuímica54Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.info:eu-repo/semantics/publishedVersionACS Publications2025info:eu-repo/semantics/article7 p.application/pdfhttp://hdl.handle.net/2072/488974https://doi.org/10.1021/jacs.5c15873RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFEDER/MCI PID2021-123801NB-I00PID2024-160739NB-I00/MICIU/AEI 10.13039/501100011033/FEDER,UEMCI/AIE (Severo Ochoa Excellence Accreditation 2002-2023 CEX2019-000925-S)L.Z. thanks Deutsche Forschungsgemeinschaft (DFG) for a postdoctoral fellowshipH.L. thanks China Scholarship Council (CSC) for a predoctoral fellowshipAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2072/4889742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
title Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
spellingShingle Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
Zhang, Liangliang
Química
54
title_short Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
title_full Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
title_fullStr Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
title_full_unstemmed Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
title_sort Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
dc.creator.none.fl_str_mv Zhang, Liangliang
Liu, Huilin
Santiago, Tomás G.
Martin, Ruben
author Zhang, Liangliang
author_facet Zhang, Liangliang
Liu, Huilin
Santiago, Tomás G.
Martin, Ruben
author_role author
author2 Liu, Huilin
Santiago, Tomás G.
Martin, Ruben
author2_role author
author
author
dc.subject.none.fl_str_mv Química
54
topic Química
54
description Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/488974
https://doi.org/10.1021/jacs.5c15873
url http://hdl.handle.net/2072/488974
https://doi.org/10.1021/jacs.5c15873
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEDER/MCI PID2021-123801NB-I00
PID2024-160739NB-I00/MICIU/AEI 10.13039/501100011033/FEDER,UE
MCI/AIE (Severo Ochoa Excellence Accreditation 2002-2023 CEX2019-000925-S)
L.Z. thanks Deutsche Forschungsgemeinschaft (DFG) for a postdoctoral fellowship
H.L. thanks China Scholarship Council (CSC) for a predoctoral fellowship
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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