Cortical Macro- and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder

Background: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural chan...

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Autores: Pardo, J, Montal, V, Campabadal, A, Oltra, J, Uribe, C, Roura, I, Bargalló, N, Martí, MJ, Compta, Y, Iranzo, A, Fortea, J, Junqué, C, Segura, B
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p17696
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17696
http://ddd.uab.cat/record/305615
Access Level:acceso abierto
Palavra-chave:Parkinson's disease
rapid eye movement sleep behavior disorder
cortical mean diffusivity
cortical thickness
magnetic resonance imaging
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spelling Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior DisorderPardo, JMontal, VCampabadal, AOltra, JUribe, CRoura, IBargalló, NMartí, MJCompta, YIranzo, AFortea, JJunqué, CSegura, BParkinson's diseaserapid eye movement sleep behavior disordercortical mean diffusivitycortical thicknessmagnetic resonance imagingBackground: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. Objectives: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh). Methods: Twenty-two PD-pRBD, 31 PD without probable RBD (PD-nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1-weighted and diffusion-weighted magnetic resonance imaging on a 3-T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two-class group comparisons of a general linear model were performed (P < 0.05). Cohen's d effect size for both approaches was computed. Results: PD-pRBD patients showed higher cMD than PD-nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule (d > 0.8), whereas CTh did not detect significant differences. PD-pRBD patients also showed increased bilateral posterior cMD in comparison with HCs (d > 0.8). These results partially overlapped with CTh results (0.5 < d < 0.8). PD-nonpRBD patients showed no differences in cMD when compared with HCs but showed cortical thinning in the left fusiform gyrus and lateral occipital cortex bilaterally (d > 0.5). Conclusions: cMD may be more sensitive than CTh displaying significant cortico-structural differences between PD subgroups, indicating this imaging biomarker's utility in studying early cortical changes in PD. (c) 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.WILEY2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17696http://ddd.uab.cat/record/305615MOVEMENT DISORDERSISSN: 08853185ISSNe: 15318257reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p176962026-06-14T12:41:47Z
dc.title.none.fl_str_mv Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
title Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
spellingShingle Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
Pardo, J
Parkinson's disease
rapid eye movement sleep behavior disorder
cortical mean diffusivity
cortical thickness
magnetic resonance imaging
title_short Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
title_full Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
title_fullStr Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
title_full_unstemmed Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
title_sort Cortical Macro- and Microstructural Changes in Parkinson&apos;s Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
dc.creator.none.fl_str_mv Pardo, J
Montal, V
Campabadal, A
Oltra, J
Uribe, C
Roura, I
Bargalló, N
Martí, MJ
Compta, Y
Iranzo, A
Fortea, J
Junqué, C
Segura, B
author Pardo, J
author_facet Pardo, J
Montal, V
Campabadal, A
Oltra, J
Uribe, C
Roura, I
Bargalló, N
Martí, MJ
Compta, Y
Iranzo, A
Fortea, J
Junqué, C
Segura, B
author_role author
author2 Montal, V
Campabadal, A
Oltra, J
Uribe, C
Roura, I
Bargalló, N
Martí, MJ
Compta, Y
Iranzo, A
Fortea, J
Junqué, C
Segura, B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Parkinson's disease
rapid eye movement sleep behavior disorder
cortical mean diffusivity
cortical thickness
magnetic resonance imaging
topic Parkinson's disease
rapid eye movement sleep behavior disorder
cortical mean diffusivity
cortical thickness
magnetic resonance imaging
description Background: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. Objectives: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh). Methods: Twenty-two PD-pRBD, 31 PD without probable RBD (PD-nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1-weighted and diffusion-weighted magnetic resonance imaging on a 3-T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two-class group comparisons of a general linear model were performed (P < 0.05). Cohen's d effect size for both approaches was computed. Results: PD-pRBD patients showed higher cMD than PD-nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule (d > 0.8), whereas CTh did not detect significant differences. PD-pRBD patients also showed increased bilateral posterior cMD in comparison with HCs (d > 0.8). These results partially overlapped with CTh results (0.5 < d < 0.8). PD-nonpRBD patients showed no differences in cMD when compared with HCs but showed cortical thinning in the left fusiform gyrus and lateral occipital cortex bilaterally (d > 0.5). Conclusions: cMD may be more sensitive than CTh displaying significant cortico-structural differences between PD subgroups, indicating this imaging biomarker's utility in studying early cortical changes in PD. (c) 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17696
http://ddd.uab.cat/record/305615
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17696
http://ddd.uab.cat/record/305615
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv MOVEMENT DISORDERS
ISSN: 08853185
ISSNe: 15318257
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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