Asymmetric hetero Diels-Alder as an access to carbacephams

A short and efficient asymmetric synthesis of the (6R,7S)-7-tert-butoxycarbonylamino-2-ketocarbacepham is described. The key step involves the hetero Diels-Alder reaction of the benzylimine derived from the enantiomer of Garner's aldehyde with Danishefsky's diene.

Detalhes bibliográficos
Autores: Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], Cativiela, C., Corzana, F. [0000-0001-5597-8127], Peregrina, J.M. [0000-0003-3778-7065], Zurbano, M.M. [0000-0001-6370-3537]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2002
País:España
Recursos:Universidad de La Rioja (UR)
Repositório:RIUR. Repositorio Institucional de la Universidad de La Rioja
OAI Identifier:oai:portal.dialnet.es:doc/5bbc6905b750603269e8139e
Acesso em linha:https://investigacion.unirioja.es/documentos/5bbc6905b750603269e8139e
Access Level:Acceso aberto
Descrição
Resumo:A short and efficient asymmetric synthesis of the (6R,7S)-7-tert-butoxycarbonylamino-2-ketocarbacepham is described. The key step involves the hetero Diels-Alder reaction of the benzylimine derived from the enantiomer of Garner's aldehyde with Danishefsky's diene.