Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma

Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrosp...

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Detalles Bibliográficos
Autores: Tejera Vaquerizo, Antonio, Nagore, Eduardo, Puig i Sardà, Susana, Robert, Caroline, Saiag, Philippe, Martín-Cuevas, Paula, Gallego, Elena, Herrera Acosta, Enrique, Aguilera, José, Malvehy, J. (Josep), Carrera Álvarez, Cristina, Cavalcanti, Andrea, Rull, Ramón, Vilalta Solsona, Antonio, Lannoy, Emilie, Boutros, Celine, Benannoune, Naima, Tomasic, Gorana, Aegerte, Philippe, Vidal i Sicart, Sergi, Palou, Josep, Alós i Hernández, Llúcia, Requena, Celia, Traves, Víctor, Pla, Ángel, Bolumar, Isidro, Soriano, Virtudes, Guillén, Carlos, Herrera Ceballos, Enrique
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/130565
Acceso en línea:https://hdl.handle.net/2445/130565
Access Level:acceso abierto
Palabra clave:Melanoma
Càncer de pell
Nodes limfàtics
Skin cancer
Lymph nodes
Descripción
Sumario:Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma.

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