Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma

The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed...

Descripción completa

Detalles Bibliográficos
Autores: Tejera-Vaquerizo, Antonio|||0000-0002-8987-0744, Boada, Aram|||0000-0001-9809-5308, Ribero, Simone, Puig, Susana|||0000-0003-1337-9745, Paradela, Sabela|||0000-0002-6779-6459, Moreno-Ramírez, David|||0000-0002-1301-7974, Cañueto, Javier, de Unamuno-Bustos, Blanca, Brinca, Ana, Descalzo-Gallego, Miguel A., Osella-Abate, Simona|||0000-0002-9886-7694, Cassoni, Paola|||0000-0003-1977-7410, Podlipnik, Sebastian|||0000-0003-4150-0522, Carrera, Cristina|||0000-0003-1608-8820, Vidal-Sicart, Sergi|||0000-0002-6303-3606, Pigem, Ramón|||0000-0002-3224-8241, Toll Abelló, Agustí|||0000-0003-2656-0076, Rull, Ramón|||0000-0002-8345-4598, Alos, Llucìa|||0000-0002-3460-0384, Requena, Celia, Bolumar, Isidro, Traves, Víctor, Pla, Ángel, Fernández-Orland, Almudena, Jaka, Ane|||0000-0003-2699-1159, Fernández-Figueras, Maria Teresa|||0000-0002-2366-7110, Richarz, Nina Anika|||0000-0003-0027-8769, Vieira, Ricardo, Botella-Estrada, Rafael, Román-Curto, Concepción|||0000-0001-6147-9412, Ferrándiz-Pulido, Lara, Iglesias-Pena, Nicolás|||0000-0002-7282-5015, Ferrándiz, Carlos|||0000-0001-9030-8399, Malvehy, Josep|||0000-0002-6998-914X, Quaglino, Pietro, Nagore, Eduardo|||0000-0003-3433-8707
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:282870
Acceso en línea:https://ddd.uab.cat/record/282870
https://dx.doi.org/urn:doi:10.3390/jcm10245878
Access Level:acceso abierto
Palabra clave:Melanoma
Sentinel lymph node biopsy
Survival
Descripción
Sumario:The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.

Similares en LA Referencia