The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis
[Background:] Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Screening of high risk populations and early diagnosis of CRC are of great importance. Tissue factor pathway inhibitor 2 (TFPI2) methylation is an important indicator for screening CRC. However, the sensitivity...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/400628 |
| Acceso en línea: | http://hdl.handle.net/10261/400628 https://api.elsevier.com/content/abstract/scopus_id/105009641598 |
| Access Level: | acceso abierto |
| Palabra clave: | Colorectal cancer (CRC) Meta-analysis Methylation Tissue factor pathway inhibitor 2 (TFPI2) |
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oai:digital.csic.es:10261/400628 |
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España |
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| dc.title.none.fl_str_mv |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| title |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| spellingShingle |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis Wang, Xiao-Ling Colorectal cancer (CRC) Meta-analysis Methylation Tissue factor pathway inhibitor 2 (TFPI2) |
| title_short |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| title_full |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| title_fullStr |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| title_full_unstemmed |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| title_sort |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis |
| dc.creator.none.fl_str_mv |
Wang, Xiao-Ling Qin, Shuo Liu, Li Jia, Yu-Qi Wang, Ying Zhou, Yu-Jie Ramos-Molina, Bruno Valladares-Ayerbes, Manuel Eidens, Moritz Liu, Zhi-Zhen |
| author |
Wang, Xiao-Ling |
| author_facet |
Wang, Xiao-Ling Qin, Shuo Liu, Li Jia, Yu-Qi Wang, Ying Zhou, Yu-Jie Ramos-Molina, Bruno Valladares-Ayerbes, Manuel Eidens, Moritz Liu, Zhi-Zhen |
| author_role |
author |
| author2 |
Qin, Shuo Liu, Li Jia, Yu-Qi Wang, Ying Zhou, Yu-Jie Ramos-Molina, Bruno Valladares-Ayerbes, Manuel Eidens, Moritz Liu, Zhi-Zhen |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Natural Science Foundation of Shanxi Province Shanxi Province Valladares-Ayerbes, Manuel [0000-0002-7950-9584] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Colorectal cancer (CRC) Meta-analysis Methylation Tissue factor pathway inhibitor 2 (TFPI2) |
| topic |
Colorectal cancer (CRC) Meta-analysis Methylation Tissue factor pathway inhibitor 2 (TFPI2) |
| description |
[Background:] Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Screening of high risk populations and early diagnosis of CRC are of great importance. Tissue factor pathway inhibitor 2 (TFPI2) methylation is an important indicator for screening CRC. However, the sensitivity and specificity of TFPI2 methylation vary significantly across different studies, and its diagnostic performance is susceptible to the influence of detection methods and sample types. This study set out to evaluate the diagnostic value of TFPI2 methylation in blood and stool samples for CRC. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/400628 https://api.elsevier.com/content/abstract/scopus_id/105009641598 |
| url |
http://hdl.handle.net/10261/400628 https://api.elsevier.com/content/abstract/scopus_id/105009641598 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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https://doi.org/10.21037/jgo-2025-319 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
AME Publishing |
| publisher.none.fl_str_mv |
AME Publishing |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869408892604121088 |
| spelling |
The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysisWang, Xiao-LingQin, ShuoLiu, LiJia, Yu-QiWang, YingZhou, Yu-JieRamos-Molina, BrunoValladares-Ayerbes, ManuelEidens, MoritzLiu, Zhi-ZhenColorectal cancer (CRC)Meta-analysisMethylationTissue factor pathway inhibitor 2 (TFPI2)[Background:] Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Screening of high risk populations and early diagnosis of CRC are of great importance. Tissue factor pathway inhibitor 2 (TFPI2) methylation is an important indicator for screening CRC. However, the sensitivity and specificity of TFPI2 methylation vary significantly across different studies, and its diagnostic performance is susceptible to the influence of detection methods and sample types. This study set out to evaluate the diagnostic value of TFPI2 methylation in blood and stool samples for CRC.[Methods:] A search strategy based on the Population, Intervention, Comparison, Outcomes and Study (PICOS) principle was employed to retrieve relevant literatures from the PubMed, Web of Science, and EMBASE databases focused on the diagnosis of CRC patients with TFPI2 methylation. The literature must include the following details: the types of tissue samples tested, detailed sample sizes of both control and case groups, comprehensive diagnostic parameters, and specific methodologies for methylation detection. The quality of the included articles was evaluated using the guidelines for the Quality Assessment of Diagnostic Accuracy Studies (QUADAS). Deeks’ funnel plot was used for the assessment of the publication bias. Data were extracted from the studies, and the random-effects model was used for the meta-analysis.[Results:] In total, 14 diagnostic test accuracy studies, comprising 3,330 subjects (1,983 CRC patients and 1,347 non-CRC controls), were included in the meta-analysis. The meta-analysis demonstrated a non-significant publication bias (P=0.29). Meta-regression further identified country, detection methodology, and sample type as significant contributors to heterogeneity. The combined sensitivity and specificity of TFPI2 in diagnosing CRC were 0.83 [95% confidence interval (CI): 0.72–0.91] and 0.96 (95% CI: 0.93–0.97), respectively. While the combined positive likelihood ratio (PLR) was 19.2 (95% CI: 11.1–33.5), the combined negative likelihood ratio (NLR) was 0.18 (95% CI: 0.10–0.31), the diagnostic odds ratio (DOR) was 109 (95% CI: 45–261), and the area under the summary receiver operating characteristic curve (SROC) for the included studies was 0.97 (95% CI: 0.95–0.98).[Conclusions:] Our findings showed that TFPI2 methylation in blood and stool samples could be a potential biomarker for the detection of CRC. TFPI2 methylation demonstrates potential as a non-invasive screening tool and dynamic monitoring biomarker for CRC, offering a complementary or alternative approach to invasive procedures such as colonoscopy. This is particularly applicable for preliminary risk stratification in populations with low screening adherence or high-risk profiles.This work was supported by the Health Commission Fund of Shanxi Province (No. 2021081); the Shanxi Administration of Traditional Chinese Medicine (No. 2023ZYYDA2001); the Young Scientists Fund of the Basic Research Project of Shanxi Province (No. 202303021222369); and the Shanxi Academy of Traditional Chinese Medicine (Nos. 202301 and 202404).Peer reviewedAME PublishingNatural Science Foundation of Shanxi ProvinceShanxi ProvinceValladares-Ayerbes, Manuel [0000-0002-7950-9584]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/400628https://api.elsevier.com/content/abstract/scopus_id/105009641598reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.21037/jgo-2025-319Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4006282026-05-22T06:33:51Z |
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15,811543 |