Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD
Rationale: Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective: To explore the a...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/66271 |
| Acceso en línea: | https://hdl.handle.net/10171/66271 |
| Access Level: | acceso abierto |
| Palabra clave: | Emphysema COPD Low bone mineral density Osteopenia Osteoporosis Smokers |
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Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPDGonzález, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095Rivera-Ortega, P. (Pilar)|||/items/4ea803c4-6633-42d9-b4ef-ffb85bad02f3Rodriguez-Fraile, M. (Macarena)|||/items/431e1418-ba87-4b39-828b-55ba49df44f5Restituto, P. (Patricia)|||/items/9e3cf4f8-e6b7-4700-b61b-40fe8472f38fColina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65Calleja, M. (María)|||/items/a7162695-4464-45e8-8b40-752430aa2469Alcaide-Ocaña, A.B. (Ana Belén)|||/items/1ae0fd26-692b-40b5-8d95-2e8252c64edaCampo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367Bertó-Botella, J.A. (Juan Antonio)|||/items/b0366e29-c1f2-45af-9925-ed328664230dSeijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9aePerez-Warnisher, M.T. (María Teresa)|||/items/e66261a8-4724-4bbc-bc8f-f1fcdd2c8a3cZulueta, J. (Javier)|||/items/1979cb86-b86c-41b7-8494-1f00acb7eb1fVaro-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001fTorres-Tajes, J.P. (Juan Pablo) de|||/items/b7010baa-6964-4f25-a3e0-7e5586fb3f4cEmphysemaCOPDLow bone mineral densityOsteopeniaOsteoporosisSmokersRationale: Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective: To explore the association between the different emphysema subtypes and the presence of low bone mineral density in a population of active or former smokers with and without chronic obstructive pulmonary disease (COPD). Methods: One hundred and fifty-three active and former smokers from a pulmonary clinic completed clinical questionnaires, pulmonary function tests, a low-dose chest computed tomography (LDCT) and a dual-energy absorptiometry (DXA) scans. Subjects were classified as having normal BMD or low BMD (osteopenia or osteoporosis). Emphysema was classified visually for its subtype and severity. Logistic regression analysis explored the relationship between the different emphysema subtypes and the presence of low BMD adjusting for other important factors. Results: Seventy-five percent of the patients had low BMD (78 had osteopenia and 37 had osteoporosis). Emphysema was more frequent (66.1 vs 26.3%, p=<0.001) and severe in those with low BMD. Multivariable analysis adjusting for other significant cofactors (age, sex, FEV1, and severity of emphysema) showed that BMI (OR=0.91, 95% CI: 0.76–0.92) and centrilobular emphysema (OR=26.19, 95% CI: 1.71 to 399.44) were associated with low BMD. Conclusion: Low BMD is highly prevalent in current and former smokers. BMI and centrilobular emphysema are strong and independent predictors of its presence, which suggests that they should be considered when evaluating smokers at risk for low BMD.Dadun. Depósito Académico Digital Universidad de Navarra20232023-05-1720202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/66271reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/662712026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| title |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| spellingShingle |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD González, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095 Emphysema COPD Low bone mineral density Osteopenia Osteoporosis Smokers |
| title_short |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| title_full |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| title_fullStr |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| title_full_unstemmed |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| title_sort |
Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD |
| dc.creator.none.fl_str_mv |
González, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095 Rivera-Ortega, P. (Pilar)|||/items/4ea803c4-6633-42d9-b4ef-ffb85bad02f3 Rodriguez-Fraile, M. (Macarena)|||/items/431e1418-ba87-4b39-828b-55ba49df44f5 Restituto, P. (Patricia)|||/items/9e3cf4f8-e6b7-4700-b61b-40fe8472f38f Colina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Calleja, M. (María)|||/items/a7162695-4464-45e8-8b40-752430aa2469 Alcaide-Ocaña, A.B. (Ana Belén)|||/items/1ae0fd26-692b-40b5-8d95-2e8252c64eda Campo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367 Bertó-Botella, J.A. (Juan Antonio)|||/items/b0366e29-c1f2-45af-9925-ed328664230d Seijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9ae Perez-Warnisher, M.T. (María Teresa)|||/items/e66261a8-4724-4bbc-bc8f-f1fcdd2c8a3c Zulueta, J. (Javier)|||/items/1979cb86-b86c-41b7-8494-1f00acb7eb1f Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Torres-Tajes, J.P. (Juan Pablo) de|||/items/b7010baa-6964-4f25-a3e0-7e5586fb3f4c |
| author |
González, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095 |
| author_facet |
González, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095 Rivera-Ortega, P. (Pilar)|||/items/4ea803c4-6633-42d9-b4ef-ffb85bad02f3 Rodriguez-Fraile, M. (Macarena)|||/items/431e1418-ba87-4b39-828b-55ba49df44f5 Restituto, P. (Patricia)|||/items/9e3cf4f8-e6b7-4700-b61b-40fe8472f38f Colina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Calleja, M. (María)|||/items/a7162695-4464-45e8-8b40-752430aa2469 Alcaide-Ocaña, A.B. (Ana Belén)|||/items/1ae0fd26-692b-40b5-8d95-2e8252c64eda Campo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367 Bertó-Botella, J.A. (Juan Antonio)|||/items/b0366e29-c1f2-45af-9925-ed328664230d Seijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9ae Perez-Warnisher, M.T. (María Teresa)|||/items/e66261a8-4724-4bbc-bc8f-f1fcdd2c8a3c Zulueta, J. (Javier)|||/items/1979cb86-b86c-41b7-8494-1f00acb7eb1f Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Torres-Tajes, J.P. (Juan Pablo) de|||/items/b7010baa-6964-4f25-a3e0-7e5586fb3f4c |
| author_role |
author |
| author2 |
Rivera-Ortega, P. (Pilar)|||/items/4ea803c4-6633-42d9-b4ef-ffb85bad02f3 Rodriguez-Fraile, M. (Macarena)|||/items/431e1418-ba87-4b39-828b-55ba49df44f5 Restituto, P. (Patricia)|||/items/9e3cf4f8-e6b7-4700-b61b-40fe8472f38f Colina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Calleja, M. (María)|||/items/a7162695-4464-45e8-8b40-752430aa2469 Alcaide-Ocaña, A.B. (Ana Belén)|||/items/1ae0fd26-692b-40b5-8d95-2e8252c64eda Campo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367 Bertó-Botella, J.A. (Juan Antonio)|||/items/b0366e29-c1f2-45af-9925-ed328664230d Seijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9ae Perez-Warnisher, M.T. (María Teresa)|||/items/e66261a8-4724-4bbc-bc8f-f1fcdd2c8a3c Zulueta, J. (Javier)|||/items/1979cb86-b86c-41b7-8494-1f00acb7eb1f Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Torres-Tajes, J.P. (Juan Pablo) de|||/items/b7010baa-6964-4f25-a3e0-7e5586fb3f4c |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Emphysema COPD Low bone mineral density Osteopenia Osteoporosis Smokers |
| topic |
Emphysema COPD Low bone mineral density Osteopenia Osteoporosis Smokers |
| description |
Rationale: Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective: To explore the association between the different emphysema subtypes and the presence of low bone mineral density in a population of active or former smokers with and without chronic obstructive pulmonary disease (COPD). Methods: One hundred and fifty-three active and former smokers from a pulmonary clinic completed clinical questionnaires, pulmonary function tests, a low-dose chest computed tomography (LDCT) and a dual-energy absorptiometry (DXA) scans. Subjects were classified as having normal BMD or low BMD (osteopenia or osteoporosis). Emphysema was classified visually for its subtype and severity. Logistic regression analysis explored the relationship between the different emphysema subtypes and the presence of low BMD adjusting for other important factors. Results: Seventy-five percent of the patients had low BMD (78 had osteopenia and 37 had osteoporosis). Emphysema was more frequent (66.1 vs 26.3%, p=<0.001) and severe in those with low BMD. Multivariable analysis adjusting for other significant cofactors (age, sex, FEV1, and severity of emphysema) showed that BMI (OR=0.91, 95% CI: 0.76–0.92) and centrilobular emphysema (OR=26.19, 95% CI: 1.71 to 399.44) were associated with low BMD. Conclusion: Low BMD is highly prevalent in current and former smokers. BMI and centrilobular emphysema are strong and independent predictors of its presence, which suggests that they should be considered when evaluating smokers at risk for low BMD. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01 2020 2020-01-01 2023 2023-05-17 |
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journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/66271 |
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https://hdl.handle.net/10171/66271 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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