Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD

Rationale: Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective: To explore the a...

Descripción completa

Detalles Bibliográficos
Autores: González, J. (Jessica)|||/items/e5760e3f-dc3f-4e0c-bc26-514288c98095, Rivera-Ortega, P. (Pilar)|||/items/4ea803c4-6633-42d9-b4ef-ffb85bad02f3, Rodriguez-Fraile, M. (Macarena)|||/items/431e1418-ba87-4b39-828b-55ba49df44f5, Restituto, P. (Patricia)|||/items/9e3cf4f8-e6b7-4700-b61b-40fe8472f38f, Colina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65, Calleja, M. (María)|||/items/a7162695-4464-45e8-8b40-752430aa2469, Alcaide-Ocaña, A.B. (Ana Belén)|||/items/1ae0fd26-692b-40b5-8d95-2e8252c64eda, Campo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367, Bertó-Botella, J.A. (Juan Antonio)|||/items/b0366e29-c1f2-45af-9925-ed328664230d, Seijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9ae, Perez-Warnisher, M.T. (María Teresa)|||/items/e66261a8-4724-4bbc-bc8f-f1fcdd2c8a3c, Zulueta, J. (Javier)|||/items/1979cb86-b86c-41b7-8494-1f00acb7eb1f, Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f, Torres-Tajes, J.P. (Juan Pablo) de|||/items/b7010baa-6964-4f25-a3e0-7e5586fb3f4c
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/66271
Acceso en línea:https://hdl.handle.net/10171/66271
Access Level:acceso abierto
Palabra clave:Emphysema
COPD
Low bone mineral density
Osteopenia
Osteoporosis
Smokers
Descripción
Sumario:Rationale: Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective: To explore the association between the different emphysema subtypes and the presence of low bone mineral density in a population of active or former smokers with and without chronic obstructive pulmonary disease (COPD). Methods: One hundred and fifty-three active and former smokers from a pulmonary clinic completed clinical questionnaires, pulmonary function tests, a low-dose chest computed tomography (LDCT) and a dual-energy absorptiometry (DXA) scans. Subjects were classified as having normal BMD or low BMD (osteopenia or osteoporosis). Emphysema was classified visually for its subtype and severity. Logistic regression analysis explored the relationship between the different emphysema subtypes and the presence of low BMD adjusting for other important factors. Results: Seventy-five percent of the patients had low BMD (78 had osteopenia and 37 had osteoporosis). Emphysema was more frequent (66.1 vs 26.3%, p=<0.001) and severe in those with low BMD. Multivariable analysis adjusting for other significant cofactors (age, sex, FEV1, and severity of emphysema) showed that BMI (OR=0.91, 95% CI: 0.76–0.92) and centrilobular emphysema (OR=26.19, 95% CI: 1.71 to 399.44) were associated with low BMD. Conclusion: Low BMD is highly prevalent in current and former smokers. BMI and centrilobular emphysema are strong and independent predictors of its presence, which suggests that they should be considered when evaluating smokers at risk for low BMD.

Similares en LA Referencia