Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors

Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geom...

Descripción completa

Detalles Bibliográficos
Autores: Álvarez, Rafael, Muñoz-Piña, Sandra, González, Maria U., Izquierdo Barba, Isabel, Fernández-Martín, Iván, Jiménez Rico, Víctor, Arcos Navarrete, Daniel, García-Valenzuela, Aurelio, Palmero, Alberto, Vallet Regí, María Dulce Nombre, González-Elipe, Agustín R., García-Martín, José R.
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/13527
Acceso en línea:https://hdl.handle.net/20.500.14352/13527
Access Level:acceso abierto
Palabra clave:615.46
546
Magnetron Sputtering
Oblique Angle Deposition
Nanostructured Titanium Thin Films
Antibacterial Coatings
Osteoblast Proliferation
Industrial Scale
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
id ES_5376e2fdd3bd2f050b2328427d844c8b
oai_identifier_str oai:docta.ucm.es:20.500.14352/13527
network_acronym_str ES
network_name_str España
repository_id_str
spelling Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial ReactorsÁlvarez, RafaelMuñoz-Piña, SandraGonzález, Maria U.Izquierdo Barba, IsabelFernández-Martín, IvánJiménez Rico, VíctorArcos Navarrete, DanielGarcía-Valenzuela, AurelioPalmero, AlbertoVallet Regí, María Dulce NombreGonzález-Elipe, Agustín R.García-Martín, José R.615.46546Magnetron SputteringOblique Angle DepositionNanostructured Titanium Thin FilmsAntibacterial CoatingsOsteoblast ProliferationIndustrial ScaleMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de MaterialesBased on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (Depuy Synthes) and a pseudo-rectangular bone plate extracted from a patient have been coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments have been performed: analysis of bacterial adhesion and biofilm formation, and osteoblasts-bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior towards osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.MDPIUniversidad Complutense de Madrid20192019-08-2820192019-08-28journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/13527reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/135272026-06-02T12:44:21Z
dc.title.none.fl_str_mv Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
title Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
spellingShingle Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
Álvarez, Rafael
615.46
546
Magnetron Sputtering
Oblique Angle Deposition
Nanostructured Titanium Thin Films
Antibacterial Coatings
Osteoblast Proliferation
Industrial Scale
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
title_short Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
title_full Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
title_fullStr Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
title_full_unstemmed Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
title_sort Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
dc.creator.none.fl_str_mv Álvarez, Rafael
Muñoz-Piña, Sandra
González, Maria U.
Izquierdo Barba, Isabel
Fernández-Martín, Iván
Jiménez Rico, Víctor
Arcos Navarrete, Daniel
García-Valenzuela, Aurelio
Palmero, Alberto
Vallet Regí, María Dulce Nombre
González-Elipe, Agustín R.
García-Martín, José R.
author Álvarez, Rafael
author_facet Álvarez, Rafael
Muñoz-Piña, Sandra
González, Maria U.
Izquierdo Barba, Isabel
Fernández-Martín, Iván
Jiménez Rico, Víctor
Arcos Navarrete, Daniel
García-Valenzuela, Aurelio
Palmero, Alberto
Vallet Regí, María Dulce Nombre
González-Elipe, Agustín R.
García-Martín, José R.
author_role author
author2 Muñoz-Piña, Sandra
González, Maria U.
Izquierdo Barba, Isabel
Fernández-Martín, Iván
Jiménez Rico, Víctor
Arcos Navarrete, Daniel
García-Valenzuela, Aurelio
Palmero, Alberto
Vallet Regí, María Dulce Nombre
González-Elipe, Agustín R.
García-Martín, José R.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.46
546
Magnetron Sputtering
Oblique Angle Deposition
Nanostructured Titanium Thin Films
Antibacterial Coatings
Osteoblast Proliferation
Industrial Scale
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
topic 615.46
546
Magnetron Sputtering
Oblique Angle Deposition
Nanostructured Titanium Thin Films
Antibacterial Coatings
Osteoblast Proliferation
Industrial Scale
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
description Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (Depuy Synthes) and a pseudo-rectangular bone plate extracted from a patient have been coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments have been performed: analysis of bacterial adhesion and biofilm formation, and osteoblasts-bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior towards osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-08-28
2019
2019-08-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/13527
url https://hdl.handle.net/20.500.14352/13527
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408118485549056
score 15,300719

Similares en LA Referencia