Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems

We report the syntheses and characterization of a series of compounds based on 1,10-phenanthroline covalently tethered, at the 2 and 9 positions, to either two benzene, naphthalene, acridine or anthracene chromophores. The acridine and anthracene derivatives are shown to efficiently cleave pUC19 pla...

Descripción completa

Detalles Bibliográficos
Autores: Gude Rodríguez, Lourdes|||0000-0002-0220-3755, Fernández Domínguez, María José, Grant, Kathryn B., Lorente Pérez, Antonio
Tipo de recurso: artículo
Fecha de publicación:2005
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/65009
Acceso en línea:http://hdl.handle.net/10017/65009
https://dx.doi.org/10.1039/b502485d
Access Level:acceso abierto
Palabra clave:Química
Chemistry
id ES_51e4e398cdfa73cf340f34817cec4315
oai_identifier_str oai:ebuah.uah.es:10017/65009
network_acronym_str ES
network_name_str España
repository_id_str
spelling Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systemsGude Rodríguez, Lourdes|||0000-0002-0220-3755Fernández Domínguez, María JoséGrant, Kathryn B.Lorente Pérez, AntonioQuímicaChemistryWe report the syntheses and characterization of a series of compounds based on 1,10-phenanthroline covalently tethered, at the 2 and 9 positions, to either two benzene, naphthalene, acridine or anthracene chromophores. The acridine and anthracene derivatives are shown to efficiently cleave pUC19 plasmid DNA upon irradiation with ultraviolet light (pH = 7.0, 22 °C, 350 nm). Furthermore, photocleavage levels are markedly increased by the addition of Cu2+ to the DNA photolysis reactions. Interestingly, when the concentrations of the anthracene compounds are lowered from 35 µM to 0.25 µM, the reverse trend is observed. DNA photocleavage is markedly reduced in the presence of copper(II).Comisión Interministerial de Ciencia y Tecnología (CICYT)The National Science FoundationThe Royal Society of Chemistry20052005-04-18journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/65009https://dx.doi.org/10.1039/b502485dreponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/650092026-06-18T11:13:07Z
dc.title.none.fl_str_mv Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
title Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
spellingShingle Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
Gude Rodríguez, Lourdes|||0000-0002-0220-3755
Química
Chemistry
title_short Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
title_full Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
title_fullStr Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
title_full_unstemmed Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
title_sort Syntheses and copper(II)-dependent DNA photocleavage by acridine and anthracene 1,10-phenanthroline conjugate systems
dc.creator.none.fl_str_mv Gude Rodríguez, Lourdes|||0000-0002-0220-3755
Fernández Domínguez, María José
Grant, Kathryn B.
Lorente Pérez, Antonio
author Gude Rodríguez, Lourdes|||0000-0002-0220-3755
author_facet Gude Rodríguez, Lourdes|||0000-0002-0220-3755
Fernández Domínguez, María José
Grant, Kathryn B.
Lorente Pérez, Antonio
author_role author
author2 Fernández Domínguez, María José
Grant, Kathryn B.
Lorente Pérez, Antonio
author2_role author
author
author
dc.subject.none.fl_str_mv Química
Chemistry
topic Química
Chemistry
description We report the syntheses and characterization of a series of compounds based on 1,10-phenanthroline covalently tethered, at the 2 and 9 positions, to either two benzene, naphthalene, acridine or anthracene chromophores. The acridine and anthracene derivatives are shown to efficiently cleave pUC19 plasmid DNA upon irradiation with ultraviolet light (pH = 7.0, 22 °C, 350 nm). Furthermore, photocleavage levels are markedly increased by the addition of Cu2+ to the DNA photolysis reactions. Interestingly, when the concentrations of the anthracene compounds are lowered from 35 µM to 0.25 µM, the reverse trend is observed. DNA photocleavage is markedly reduced in the presence of copper(II).
publishDate 2005
dc.date.none.fl_str_mv 2005
2005-04-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/65009
https://dx.doi.org/10.1039/b502485d
url http://hdl.handle.net/10017/65009
https://dx.doi.org/10.1039/b502485d
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society of Chemistry
publisher.none.fl_str_mv The Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407995740291072
score 15.811543

Similares en LA Referencia