Anthracene and naphthalene (2,2'-bipyridine) platinum (II) conjugates: synthesis and DNA photocleavage
A series of (2.2'-bipyridine)platinum(II) complexes covalently tethered to one or two anthracene or naphthalene chromophores was synthesized in high yields, The Compounds were equilibrated with pUC19 plasmid and then irradiated at 350 nm. DNA cleaving reactions showed that the complex attached...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2002 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/65011 |
| Acceso en línea: | http://hdl.handle.net/10017/65011 https://dx.doi.org/10.1016/S0040-4039(02)00937-1 |
| Access Level: | acceso abierto |
| Palabra clave: | DNA Photocleavage (2,2'-bipyridine)platinum(II) complexes Naphthalene Anthracene Química Chemistry |
| Sumario: | A series of (2.2'-bipyridine)platinum(II) complexes covalently tethered to one or two anthracene or naphthalene chromophores was synthesized in high yields, The Compounds were equilibrated with pUC19 plasmid and then irradiated at 350 nm. DNA cleaving reactions showed that the complex attached to two anthracene units exhibited the highest photocleavage efficiency, leading to complete conversion of supercoiled to linear DNA at 0.25 muM concentrations of the complex (37degreesC. pH 7.4), (C) 2002 Elsevier Science Ltd. All rights reserved. |
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