Synthesis, DNA intercalation and europium(III)-triggered DNA photocleavage by a bis-proflavine succinamide conjugate
We describe the synthesis of a bis-proflavine derivative containing a succinamide linking chain. Levels of pUC19 plasmid DNA photocleavage by this compound are significantly enhanced in the presence of Eu3+ (350 nm, 22 degreesC, pH 7.0). UV-visible spectrophotometric Studies of the ligand With Calf...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2004 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/65014 |
| Acceso en línea: | http://hdl.handle.net/10017/65014 https://dx.doi.org/10.1016/j.tetlet.2004.03.177 |
| Access Level: | acceso abierto |
| Palabra clave: | Química Chemistry |
| Sumario: | We describe the synthesis of a bis-proflavine derivative containing a succinamide linking chain. Levels of pUC19 plasmid DNA photocleavage by this compound are significantly enhanced in the presence of Eu3+ (350 nm, 22 degreesC, pH 7.0). UV-visible spectrophotometric Studies of the ligand With Calf thymus DNA show bathochromic-shifts and hypochromicity in the major absorption bands of the bis-proflavine derivative. Viscosimetric analysis of the helical extension of sonicated calf thymus DNA agrees with a monofunctional intercalation process. (C) 2004 Elsevier Ltd. All rights reserved. |
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