Maob rs3027452 modifies mood improvement after tryptophan supplementation

© 2021 Gonzalez et al.

Detalles Bibliográficos
Autores: González, Irene, Polvillo Hernández, Rocío, Ruiz‐Galdón, Maximiliano, Reyes‐Engel, Armando, Royo, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260176
Acceso en línea:http://hdl.handle.net/10261/260176
Access Level:acceso abierto
Palabra clave:Tryptophan
Serotonin
5-HT
Mood
Pharmacogenetics
Monoamine oxidase
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spelling Maob rs3027452 modifies mood improvement after tryptophan supplementationGonzález, IrenePolvillo Hernández, RocíoRuiz‐Galdón, MaximilianoReyes‐Engel, ArmandoRoyo, José LuisTryptophanSerotonin5-HTMoodPharmacogeneticsMonoamine oxidase© 2021 Gonzalez et al.[Purpose]: Tryptophan is the only precursor of serotonin, the hormone which helps regulate key human functions such as appetite, memory, mood, and sexual behavior. Connections have been identified between serotonin system dysfunction and the molecular etiology and treatment of mood disorders in a wide range of studies. Proposals have been put forward to co-administer tryptophan supplementation together with serotonin reuptake inhibitors in major depression patients, and also to exploit the sub-therapeutic depressive status in healthy populations. The reported responses, however, have been very dissimilar and this uneven effect may largely be explained by interindividual genetic differences.[Materials and Methods]: We studied mood change in 138 healthy subjects using both Goldberg’s General Health Questionnaire and the Profile of Mood States Questionnaire to determine the effects of a daily supplementation of 1g of tryptophan or placebo. Buccal DNA samples were provided and TPH1 (rs1800532), MAOA (rs3788862 and rs979605), MAOB (rs3027452), and COMT (rs6269 and rs4680) variants were genotyped.[Results]: MAOB rs3027452 was equally associated with tryptophan supplementation efficacy in the depression subscales of both questionnaires (ΔT-Score.D; ΔT-Score.TMD and ΔPOMS.D p-values < 0.01).[Conclusion]: Here we provide evidence that tryptophan supplementation has an uneven effect on mood improvement in the general population.Dove PressConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/260176reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.2147/IJGM.S305443Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2601762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Maob rs3027452 modifies mood improvement after tryptophan supplementation
title Maob rs3027452 modifies mood improvement after tryptophan supplementation
spellingShingle Maob rs3027452 modifies mood improvement after tryptophan supplementation
González, Irene
Tryptophan
Serotonin
5-HT
Mood
Pharmacogenetics
Monoamine oxidase
title_short Maob rs3027452 modifies mood improvement after tryptophan supplementation
title_full Maob rs3027452 modifies mood improvement after tryptophan supplementation
title_fullStr Maob rs3027452 modifies mood improvement after tryptophan supplementation
title_full_unstemmed Maob rs3027452 modifies mood improvement after tryptophan supplementation
title_sort Maob rs3027452 modifies mood improvement after tryptophan supplementation
dc.creator.none.fl_str_mv González, Irene
Polvillo Hernández, Rocío
Ruiz‐Galdón, Maximiliano
Reyes‐Engel, Armando
Royo, José Luis
author González, Irene
author_facet González, Irene
Polvillo Hernández, Rocío
Ruiz‐Galdón, Maximiliano
Reyes‐Engel, Armando
Royo, José Luis
author_role author
author2 Polvillo Hernández, Rocío
Ruiz‐Galdón, Maximiliano
Reyes‐Engel, Armando
Royo, José Luis
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tryptophan
Serotonin
5-HT
Mood
Pharmacogenetics
Monoamine oxidase
topic Tryptophan
Serotonin
5-HT
Mood
Pharmacogenetics
Monoamine oxidase
description © 2021 Gonzalez et al.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260176
url http://hdl.handle.net/10261/260176
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.2147/IJGM.S305443
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407747909353472
score 15.811543

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