Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial
Dear Editor, Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfac...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/119718 |
| Acceso en línea: | https://hdl.handle.net/10171/119718 |
| Access Level: | acceso abierto |
| Palabra clave: | Dyskinesia Motor cortex Parkinson's disease Transcranial magnetic stimulation tSMS. |
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Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trialDileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fdAmmann, C. (Claudia)|||/items/73115fcc-9803-4a6d-bbf6-484e6c12fd50Catanzaro, V. (Valentina)|||/items/1dbd8a53-5a47-4c04-9cc7-0e766533f36cPagge, C. (Cristina)|||/items/28b66f2f-30e1-46dc-835b-af223176b979Piredda, R. (Rosanna)|||/items/ed9e7c11-5ae7-4adf-a4f7-dfe57c222fb0Monje, M.H.G. (Mariana H. G.)|||/items/a163ab56-a02f-4905-be3c-8bcdb93c44a3Navalpotro-Gómez, I. (Irene)|||/items/a41b8eef-5add-4298-94c1-2bda081cb6d5Bergareche, A. (Alberto)|||/items/2e84e2ed-aa1d-4fb8-b9f8-6d521e1e877bRodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030Vela, L. (Lydia)|||/items/9e447b86-dc0a-4126-93ba-2696832414b3Alonso-Frech, F. (Fernando)|||/items/ca9ba973-a71a-4227-9a5d-0d8015fc4c88Catalán, M.J. (María J.)|||/items/d2c8d78d-c1a2-4434-959b-f734c7428455Molina, J.A. (José A.)|||/items/e8d4beca-3688-4a73-8fe1-27db77b7ecefLópez-Ariztegui, N. (Nuria)|||/items/828b5ced-2da7-4af5-bc65-5a575cbd3467Oliviero, A. (Antonio)|||/items/500877fb-41d8-46d3-a593-59749e67de77Obeso, J.A. (José A.)|||/items/dadded16-df40-45a3-9feb-7ece0fa4d520Foffani, G. (Guglielmo)|||/items/d8f35741-b93b-453b-9691-858f12c14f43DyskinesiaMotor cortexParkinson's diseaseTranscranial magnetic stimulationtSMS.Dear Editor, Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfactory pharmacological treatment of dyskinesias often motivates the escalation toward more advanced invasive treatments. However, even with invasive treatments dyskinesias may remain problematic. A promising approach is offered by non-invasive brain stimulation (NIBS). Several small, randomized studies (sample sizes 17 patients) suggest that presumably reducing the excitability of motor cortical areas with repetitive transcranial magnetic stimulation (rTMS) may be effective for reducing levodopa-induced dyskinesias [1]. However, rTMS is not portable, which limits its application to a center-based therapeutic model and possibly hindered the path toward larger, longer and more definitive clinical trials. We recently introduced transcranial static magnetic field stimulation (tSMS), which can reduce cortical excitability in both healthy subjects [2,3] and PD patients OFF medication [4]. Differently from rTMS, tSMS is portable, which makes it attractive for shifting the NIBS paradigm from a center-based to a home-based therapeutic model. We thus aimed to investigate the potential of tSMS as a novel non-invasive home-based treatment to manage levodopainduced dyskinesias.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/119718reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1197182026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| title |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| spellingShingle |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial Dileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fd Dyskinesia Motor cortex Parkinson's disease Transcranial magnetic stimulation tSMS. |
| title_short |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| title_full |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| title_fullStr |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| title_full_unstemmed |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| title_sort |
Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial |
| dc.creator.none.fl_str_mv |
Dileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fd Ammann, C. (Claudia)|||/items/73115fcc-9803-4a6d-bbf6-484e6c12fd50 Catanzaro, V. (Valentina)|||/items/1dbd8a53-5a47-4c04-9cc7-0e766533f36c Pagge, C. (Cristina)|||/items/28b66f2f-30e1-46dc-835b-af223176b979 Piredda, R. (Rosanna)|||/items/ed9e7c11-5ae7-4adf-a4f7-dfe57c222fb0 Monje, M.H.G. (Mariana H. G.)|||/items/a163ab56-a02f-4905-be3c-8bcdb93c44a3 Navalpotro-Gómez, I. (Irene)|||/items/a41b8eef-5add-4298-94c1-2bda081cb6d5 Bergareche, A. (Alberto)|||/items/2e84e2ed-aa1d-4fb8-b9f8-6d521e1e877b Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030 Vela, L. (Lydia)|||/items/9e447b86-dc0a-4126-93ba-2696832414b3 Alonso-Frech, F. (Fernando)|||/items/ca9ba973-a71a-4227-9a5d-0d8015fc4c88 Catalán, M.J. (María J.)|||/items/d2c8d78d-c1a2-4434-959b-f734c7428455 Molina, J.A. (José A.)|||/items/e8d4beca-3688-4a73-8fe1-27db77b7ecef López-Ariztegui, N. (Nuria)|||/items/828b5ced-2da7-4af5-bc65-5a575cbd3467 Oliviero, A. (Antonio)|||/items/500877fb-41d8-46d3-a593-59749e67de77 Obeso, J.A. (José A.)|||/items/dadded16-df40-45a3-9feb-7ece0fa4d520 Foffani, G. (Guglielmo)|||/items/d8f35741-b93b-453b-9691-858f12c14f43 |
| author |
Dileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fd |
| author_facet |
Dileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fd Ammann, C. (Claudia)|||/items/73115fcc-9803-4a6d-bbf6-484e6c12fd50 Catanzaro, V. (Valentina)|||/items/1dbd8a53-5a47-4c04-9cc7-0e766533f36c Pagge, C. (Cristina)|||/items/28b66f2f-30e1-46dc-835b-af223176b979 Piredda, R. (Rosanna)|||/items/ed9e7c11-5ae7-4adf-a4f7-dfe57c222fb0 Monje, M.H.G. (Mariana H. G.)|||/items/a163ab56-a02f-4905-be3c-8bcdb93c44a3 Navalpotro-Gómez, I. (Irene)|||/items/a41b8eef-5add-4298-94c1-2bda081cb6d5 Bergareche, A. (Alberto)|||/items/2e84e2ed-aa1d-4fb8-b9f8-6d521e1e877b Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030 Vela, L. (Lydia)|||/items/9e447b86-dc0a-4126-93ba-2696832414b3 Alonso-Frech, F. (Fernando)|||/items/ca9ba973-a71a-4227-9a5d-0d8015fc4c88 Catalán, M.J. (María J.)|||/items/d2c8d78d-c1a2-4434-959b-f734c7428455 Molina, J.A. (José A.)|||/items/e8d4beca-3688-4a73-8fe1-27db77b7ecef López-Ariztegui, N. (Nuria)|||/items/828b5ced-2da7-4af5-bc65-5a575cbd3467 Oliviero, A. (Antonio)|||/items/500877fb-41d8-46d3-a593-59749e67de77 Obeso, J.A. (José A.)|||/items/dadded16-df40-45a3-9feb-7ece0fa4d520 Foffani, G. (Guglielmo)|||/items/d8f35741-b93b-453b-9691-858f12c14f43 |
| author_role |
author |
| author2 |
Ammann, C. (Claudia)|||/items/73115fcc-9803-4a6d-bbf6-484e6c12fd50 Catanzaro, V. (Valentina)|||/items/1dbd8a53-5a47-4c04-9cc7-0e766533f36c Pagge, C. (Cristina)|||/items/28b66f2f-30e1-46dc-835b-af223176b979 Piredda, R. (Rosanna)|||/items/ed9e7c11-5ae7-4adf-a4f7-dfe57c222fb0 Monje, M.H.G. (Mariana H. G.)|||/items/a163ab56-a02f-4905-be3c-8bcdb93c44a3 Navalpotro-Gómez, I. (Irene)|||/items/a41b8eef-5add-4298-94c1-2bda081cb6d5 Bergareche, A. (Alberto)|||/items/2e84e2ed-aa1d-4fb8-b9f8-6d521e1e877b Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030 Vela, L. (Lydia)|||/items/9e447b86-dc0a-4126-93ba-2696832414b3 Alonso-Frech, F. (Fernando)|||/items/ca9ba973-a71a-4227-9a5d-0d8015fc4c88 Catalán, M.J. (María J.)|||/items/d2c8d78d-c1a2-4434-959b-f734c7428455 Molina, J.A. (José A.)|||/items/e8d4beca-3688-4a73-8fe1-27db77b7ecef López-Ariztegui, N. (Nuria)|||/items/828b5ced-2da7-4af5-bc65-5a575cbd3467 Oliviero, A. (Antonio)|||/items/500877fb-41d8-46d3-a593-59749e67de77 Obeso, J.A. (José A.)|||/items/dadded16-df40-45a3-9feb-7ece0fa4d520 Foffani, G. (Guglielmo)|||/items/d8f35741-b93b-453b-9691-858f12c14f43 |
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author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Dyskinesia Motor cortex Parkinson's disease Transcranial magnetic stimulation tSMS. |
| topic |
Dyskinesia Motor cortex Parkinson's disease Transcranial magnetic stimulation tSMS. |
| description |
Dear Editor, Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfactory pharmacological treatment of dyskinesias often motivates the escalation toward more advanced invasive treatments. However, even with invasive treatments dyskinesias may remain problematic. A promising approach is offered by non-invasive brain stimulation (NIBS). Several small, randomized studies (sample sizes 17 patients) suggest that presumably reducing the excitability of motor cortical areas with repetitive transcranial magnetic stimulation (rTMS) may be effective for reducing levodopa-induced dyskinesias [1]. However, rTMS is not portable, which limits its application to a center-based therapeutic model and possibly hindered the path toward larger, longer and more definitive clinical trials. We recently introduced transcranial static magnetic field stimulation (tSMS), which can reduce cortical excitability in both healthy subjects [2,3] and PD patients OFF medication [4]. Differently from rTMS, tSMS is portable, which makes it attractive for shifting the NIBS paradigm from a center-based to a home-based therapeutic model. We thus aimed to investigate the potential of tSMS as a novel non-invasive home-based treatment to manage levodopainduced dyskinesias. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/119718 |
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https://hdl.handle.net/10171/119718 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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