Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia

[Background] Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes impl...

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Detalles Bibliográficos
Autores: Sosero, Yuri L., Bandres-Ciga, Sara, Ferwerda, Bart, Tocino, Maria T. P., Díaz-Belloso, Rafael, Gómez-Garre, Pilar, Faouzi, Johann, Taba, Pille, Pavelka, Lukas, Marques, Tainà M., Gomes, Clarissa P. C., Kolodkin, Alexey, May, Patrick, Milanowski, Lukasz M., Wszolek, Zbigniew K., Uitti, Ryan J., Heutink, Peter, van Hilten, Jacobus J., Simon, David K., Eberly, Shirley, Álvarez, Ignacio, Krohn, Lynne, Yu, Eric, Freeman, Kathryn, Rudakou, Uladzislau, Ruskey, Jennifer A., Asayesh, Farnaz, Menéndez-González, Manuel, Pastor, Pau, Ross, Owen A., Krüger, Rejko, Corvol, Jean-Christophe, Koks, Sulev, Mir, Pablo, De Bie, Rob M. A., Iwaki, Hirotaka, Gan-Or, Ziv
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/385691
Acceso en línea:http://hdl.handle.net/10261/385691
https://api.elsevier.com/content/abstract/scopus_id/85201301987
Access Level:acceso abierto
Palabra clave:Levodopa‐induced dyskinesia
GBA1
LRRK2
Parkinson's disease
Dopamine
Descripción
Sumario:[Background] Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes implicated in PD, including GBA1 and LRRK2.

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