Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial

Dear Editor, Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfac...

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Autores: Dileone, M. (Michele)|||/items/d0370c75-61ad-4704-a723-c23361d478fd, Ammann, C. (Claudia)|||/items/73115fcc-9803-4a6d-bbf6-484e6c12fd50, Catanzaro, V. (Valentina)|||/items/1dbd8a53-5a47-4c04-9cc7-0e766533f36c, Pagge, C. (Cristina)|||/items/28b66f2f-30e1-46dc-835b-af223176b979, Piredda, R. (Rosanna)|||/items/ed9e7c11-5ae7-4adf-a4f7-dfe57c222fb0, Monje, M.H.G. (Mariana H. G.)|||/items/a163ab56-a02f-4905-be3c-8bcdb93c44a3, Navalpotro-Gómez, I. (Irene)|||/items/a41b8eef-5add-4298-94c1-2bda081cb6d5, Bergareche, A. (Alberto)|||/items/2e84e2ed-aa1d-4fb8-b9f8-6d521e1e877b, Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030, Vela, L. (Lydia)|||/items/9e447b86-dc0a-4126-93ba-2696832414b3, Alonso-Frech, F. (Fernando)|||/items/ca9ba973-a71a-4227-9a5d-0d8015fc4c88, Catalán, M.J. (María J.)|||/items/d2c8d78d-c1a2-4434-959b-f734c7428455, Molina, J.A. (José A.)|||/items/e8d4beca-3688-4a73-8fe1-27db77b7ecef, López-Ariztegui, N. (Nuria)|||/items/828b5ced-2da7-4af5-bc65-5a575cbd3467, Oliviero, A. (Antonio)|||/items/500877fb-41d8-46d3-a593-59749e67de77, Obeso, J.A. (José A.)|||/items/dadded16-df40-45a3-9feb-7ece0fa4d520, Foffani, G. (Guglielmo)|||/items/d8f35741-b93b-453b-9691-858f12c14f43
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/119718
Acceso en línea:https://hdl.handle.net/10171/119718
Access Level:acceso abierto
Palabra clave:Dyskinesia
Motor cortex
Parkinson's disease
Transcranial magnetic stimulation
tSMS.
Descripción
Sumario:Dear Editor, Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfactory pharmacological treatment of dyskinesias often motivates the escalation toward more advanced invasive treatments. However, even with invasive treatments dyskinesias may remain problematic. A promising approach is offered by non-invasive brain stimulation (NIBS). Several small, randomized studies (sample sizes 17 patients) suggest that presumably reducing the excitability of motor cortical areas with repetitive transcranial magnetic stimulation (rTMS) may be effective for reducing levodopa-induced dyskinesias [1]. However, rTMS is not portable, which limits its application to a center-based therapeutic model and possibly hindered the path toward larger, longer and more definitive clinical trials. We recently introduced transcranial static magnetic field stimulation (tSMS), which can reduce cortical excitability in both healthy subjects [2,3] and PD patients OFF medication [4]. Differently from rTMS, tSMS is portable, which makes it attractive for shifting the NIBS paradigm from a center-based to a home-based therapeutic model. We thus aimed to investigate the potential of tSMS as a novel non-invasive home-based treatment to manage levodopainduced dyskinesias.

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