Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study

INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ indivi...

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Autores: Tort Merino, Adrià, Pérez Millan, Agnès, Falgàs Martínez, Neus, Borrego Écija, Sergi, Esteller, Diana, Bosch, Bea, Castellví, Magdalena, Juncà Parella, Jordi, Val Guardiola, Andrea, Fernández Villullas, Guadalupe, Antonell Boixader, Anna, 1978-, Sanchez-Saudinos, María Belén, Rubio Guerra, Sara, Zhu, Nuole, García Martínez, María, Pozueta, Ana, Estanga, Ainara, Ecay Torres, Mirian, Lopez de Luis, Carolina, Tainta, Mikel, Altuna, Miren, Rodriguez Rodriguez, Eloy, Sanchez Juan, Pascual, Martinez Lage, Pablo, Lleo, Alberto, Fortea, Juan, Illán Gala, Ignacio, Balasa, Mircea, Lladó Plarrumaní, Albert, Rami González, Lorena, Sánchez Valle, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/223948
Acceso en línea:https://hdl.handle.net/2445/223948
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Trastorns de la cognició
Neuropsiquiatria geriàtrica
Alzheimer's disease
Cognition disorders
Geriatric neuropsychiatry
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spelling Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort studyTort Merino, AdriàPérez Millan, AgnèsFalgàs Martínez, NeusBorrego Écija, SergiEsteller, DianaBosch, BeaCastellví, MagdalenaJuncà Parella, JordiVal Guardiola, AndreaFernández Villullas, GuadalupeAntonell Boixader, Anna, 1978-Sanchez-Saudinos, María BelénRubio Guerra, SaraZhu, NuoleGarcía Martínez, MaríaPozueta, AnaEstanga, AinaraEcay Torres, MirianLopez de Luis, CarolinaTainta, MikelAltuna, MirenRodriguez Rodriguez, EloySanchez Juan, PascualMartinez Lage, PabloLleo, AlbertoFortea, JuanIllán Gala, IgnacioBalasa, MirceaLladó Plarrumaní, AlbertRami González, LorenaSánchez Valle, RaquelMalaltia d'AlzheimerTrastorns de la cognicióNeuropsiquiatria geriàtricaAlzheimer's diseaseCognition disordersGeriatric neuropsychiatryINTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2-year follow-up. We used linear mixed-effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects. RESULTS The A beta+ group showed reduced practice effects in verbal learning (beta = -1.14, SE = 0.40, p = 0.0046) and memory function (beta = -0.56, SE = 0.19, p = 0.0035), as well as in language tasks (beta = -0.59, SE = 0.19, p = 0.0027). DISCUSSION Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials. Highlights This was a multicenter study on practice effects in asymptomatic A beta+ individuals. We used LME models to analyze cognitive trajectories across multiple domains. Practice-effects reductions might be an indicator of subtle cognitive decline. Implications on clinical and research settings within the AD field are discussed.John Wiley & Sons2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/223948Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttps://doi.org/10.1002/alz.70016Alzheimers & Dementia, 2025, vol.21, num.3, 70016https://doi.org/10.1002/alz.70016cc-by-nc (c) Tort Merino, Adrià et al., 2025http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2239482026-05-27T06:46:51Z
dc.title.none.fl_str_mv Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
title Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
spellingShingle Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
Tort Merino, Adrià
Malaltia d'Alzheimer
Trastorns de la cognició
Neuropsiquiatria geriàtrica
Alzheimer's disease
Cognition disorders
Geriatric neuropsychiatry
title_short Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
title_full Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
title_fullStr Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
title_full_unstemmed Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
title_sort Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
dc.creator.none.fl_str_mv Tort Merino, Adrià
Pérez Millan, Agnès
Falgàs Martínez, Neus
Borrego Écija, Sergi
Esteller, Diana
Bosch, Bea
Castellví, Magdalena
Juncà Parella, Jordi
Val Guardiola, Andrea
Fernández Villullas, Guadalupe
Antonell Boixader, Anna, 1978-
Sanchez-Saudinos, María Belén
Rubio Guerra, Sara
Zhu, Nuole
García Martínez, María
Pozueta, Ana
Estanga, Ainara
Ecay Torres, Mirian
Lopez de Luis, Carolina
Tainta, Mikel
Altuna, Miren
Rodriguez Rodriguez, Eloy
Sanchez Juan, Pascual
Martinez Lage, Pablo
Lleo, Alberto
Fortea, Juan
Illán Gala, Ignacio
Balasa, Mircea
Lladó Plarrumaní, Albert
Rami González, Lorena
Sánchez Valle, Raquel
author Tort Merino, Adrià
author_facet Tort Merino, Adrià
Pérez Millan, Agnès
Falgàs Martínez, Neus
Borrego Écija, Sergi
Esteller, Diana
Bosch, Bea
Castellví, Magdalena
Juncà Parella, Jordi
Val Guardiola, Andrea
Fernández Villullas, Guadalupe
Antonell Boixader, Anna, 1978-
Sanchez-Saudinos, María Belén
Rubio Guerra, Sara
Zhu, Nuole
García Martínez, María
Pozueta, Ana
Estanga, Ainara
Ecay Torres, Mirian
Lopez de Luis, Carolina
Tainta, Mikel
Altuna, Miren
Rodriguez Rodriguez, Eloy
Sanchez Juan, Pascual
Martinez Lage, Pablo
Lleo, Alberto
Fortea, Juan
Illán Gala, Ignacio
Balasa, Mircea
Lladó Plarrumaní, Albert
Rami González, Lorena
Sánchez Valle, Raquel
author_role author
author2 Pérez Millan, Agnès
Falgàs Martínez, Neus
Borrego Écija, Sergi
Esteller, Diana
Bosch, Bea
Castellví, Magdalena
Juncà Parella, Jordi
Val Guardiola, Andrea
Fernández Villullas, Guadalupe
Antonell Boixader, Anna, 1978-
Sanchez-Saudinos, María Belén
Rubio Guerra, Sara
Zhu, Nuole
García Martínez, María
Pozueta, Ana
Estanga, Ainara
Ecay Torres, Mirian
Lopez de Luis, Carolina
Tainta, Mikel
Altuna, Miren
Rodriguez Rodriguez, Eloy
Sanchez Juan, Pascual
Martinez Lage, Pablo
Lleo, Alberto
Fortea, Juan
Illán Gala, Ignacio
Balasa, Mircea
Lladó Plarrumaní, Albert
Rami González, Lorena
Sánchez Valle, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Trastorns de la cognició
Neuropsiquiatria geriàtrica
Alzheimer's disease
Cognition disorders
Geriatric neuropsychiatry
topic Malaltia d'Alzheimer
Trastorns de la cognició
Neuropsiquiatria geriàtrica
Alzheimer's disease
Cognition disorders
Geriatric neuropsychiatry
description INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2-year follow-up. We used linear mixed-effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects. RESULTS The A beta+ group showed reduced practice effects in verbal learning (beta = -1.14, SE = 0.40, p = 0.0046) and memory function (beta = -0.56, SE = 0.19, p = 0.0035), as well as in language tasks (beta = -0.59, SE = 0.19, p = 0.0027). DISCUSSION Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials. Highlights This was a multicenter study on practice effects in asymptomatic A beta+ individuals. We used LME models to analyze cognitive trajectories across multiple domains. Practice-effects reductions might be an indicator of subtle cognitive decline. Implications on clinical and research settings within the AD field are discussed.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223948
url https://hdl.handle.net/2445/223948
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1002/alz.70016
Alzheimers & Dementia, 2025, vol.21, num.3, 70016
https://doi.org/10.1002/alz.70016
dc.rights.none.fl_str_mv cc-by-nc (c) Tort Merino, Adrià et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Tort Merino, Adrià et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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