Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study

INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ indivi...

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Detalles Bibliográficos
Autores: Tort-Merino, A, Pérez-Millan, A, Falgàs, N, Borrego-ecija, S, Esteller, D, Bosch, B, Castellví, M, Juncà-Parella, J, del Val-Guardiola, A, Fernández-Villullas, G, Antonell, A, Sanchez-Saudinós, MB, Rubio-Guerra, S, Zhu, NL, García-Martínez, M, Pozueta, A, Estanga, A, Ecay-Torres, M, de Luis, CL, Tainta, M, Altuna, M, Rodríguez-Rodríguez, E, Sánchez-Juan, P, Martínez-Lage, P, Lleó, A, Fortea, J, Illán-Gala, I, Balasa, M, Lladó, A, Rami, L, Sánchez-Valle, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19478
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19478
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
cognition
early detection
neuropsychological assessment
practice effects
subtle cognitive decline
Descripción
Sumario:INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2-year follow-up. We used linear mixed-effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects. RESULTS The A beta+ group showed reduced practice effects in verbal learning (beta = -1.14, SE = 0.40, p = 0.0046) and memory function (beta = -0.56, SE = 0.19, p = 0.0035), as well as in language tasks (beta = -0.59, SE = 0.19, p = 0.0027). DISCUSSION Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials. Highlights This was a multicenter study on practice effects in asymptomatic A beta+ individuals. We used LME models to analyze cognitive trajectories across multiple domains. Practice-effects reductions might be an indicator of subtle cognitive decline. Implications on clinical and research settings within the AD field are discussed.

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