Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.

The rise of antibiotic resistance and the growing number of biofilm-related infectionsmake bacterial infections a serious threat f or global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight again...

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Detalhes bibliográficos
Autores: Colilla Nieto, Montserrat, Vallet Regí, María Dulce Nombre
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7526
Acesso em linha:https://hdl.handle.net/20.500.14352/7526
Access Level:acceso abierto
Palavra-chave:Mesoporous silica nanoparticles
bacterial infection
bacterial resistance
biofilm
targeting
antimicrobials
stimuli-responsive drug delivery.
Materiales
3312 Tecnología de Materiales
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spelling Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.Colilla Nieto, MontserratVallet Regí, María Dulce NombreMesoporous silica nanoparticlesbacterial infectionbacterial resistancebiofilmtargetingantimicrobialsstimuli-responsive drug delivery.Materiales3312 Tecnología de MaterialesThe rise of antibiotic resistance and the growing number of biofilm-related infectionsmake bacterial infections a serious threat f or global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infectiontargeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.MDPIUniversidad Complutense de Madrid20202020-11-1520202020-11-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7526reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/75262026-06-02T12:44:21Z
dc.title.none.fl_str_mv Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
title Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
spellingShingle Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
Colilla Nieto, Montserrat
Mesoporous silica nanoparticles
bacterial infection
bacterial resistance
biofilm
targeting
antimicrobials
stimuli-responsive drug delivery.
Materiales
3312 Tecnología de Materiales
title_short Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
title_full Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
title_fullStr Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
title_full_unstemmed Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
title_sort Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
dc.creator.none.fl_str_mv Colilla Nieto, Montserrat
Vallet Regí, María Dulce Nombre
author Colilla Nieto, Montserrat
author_facet Colilla Nieto, Montserrat
Vallet Regí, María Dulce Nombre
author_role author
author2 Vallet Regí, María Dulce Nombre
author2_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Mesoporous silica nanoparticles
bacterial infection
bacterial resistance
biofilm
targeting
antimicrobials
stimuli-responsive drug delivery.
Materiales
3312 Tecnología de Materiales
topic Mesoporous silica nanoparticles
bacterial infection
bacterial resistance
biofilm
targeting
antimicrobials
stimuli-responsive drug delivery.
Materiales
3312 Tecnología de Materiales
description The rise of antibiotic resistance and the growing number of biofilm-related infectionsmake bacterial infections a serious threat f or global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infectiontargeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-15
2020
2020-11-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7526
url https://hdl.handle.net/20.500.14352/7526
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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