Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates
Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reduc-tive species t...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/4414 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/4414 |
| Access Level: | acceso abierto |
| Palabra clave: | mesoporous silica nanoparticles redox-responsive stimuli-responsive drug delivery cancer cell targeting biodegradable nanoparticles periodic mesoporous organosilica nanoparticles Materiales 3312 Tecnología de Materiales |
| Sumario: | Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reduc-tive species that are found within the cells, compared to bloodstream, which leads to the drug re-lease taking place only inside cells. This review is intended to provide a comprehensive overview of the most recent trends in the design of redox-responsive mesoporous silica nanoparticles. First, a general description of the biological rationale of this stimulus is presented. Then, the different types of gatekeepers that are able to open the pore entrances only upon application of reductive conditions will be introduced. In this sense, we will distinguish among those targeted and those non-targeted toward cancer cells. Finally, a new family of bridged silica nanoparticles able to degrade their struc-ture upon application of this type of stimulus will be presented. |
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