Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain

Betanodavirus (NNV), the causative agent of viral retinopathy and encephalopathy (VER) disease in fish, is the greatest viral threat for aquaculture growth and diversification in the Mediterranean area, where several genotypes and reassortants have been described. The shi drum (Umbrina cirrosa) is a...

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Authors: Chaves-Pozo, Elena, Arizcun, Marta, Cuesta, Alberto
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/313901
Online Access:http://hdl.handle.net/10261/313901
Access Level:Open access
Keyword:Betanodavirus
Centro Oceanográfico de Murcia
Acuicultura
Mediterranean fish
Viral diseases
Clinical signs
Viral load
Shi drum
Mortalities
fish
genotypes
cytology
histology
brain
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oai_identifier_str oai:digital.csic.es:10261/313901
network_acronym_str ES
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repository_id_str
spelling Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brainChaves-Pozo, ElenaArizcun, MartaCuesta, AlbertoBetanodavirusCentro Oceanográfico de MurciaAcuiculturaMediterranean fishViral diseasesClinical signsViral loadShi drumMortalitiesfishgenotypescytologyhistologybrainBetanodavirus (NNV), the causative agent of viral retinopathy and encephalopathy (VER) disease in fish, is the greatest viral threat for aquaculture growth and diversification in the Mediterranean area, where several genotypes and reassortants have been described. The shi drum (Umbrina cirrosa) is an excellent candidate for marine aquaculture diversification in the Mediterranean area, as this species is easily adapted to culture conditions and shows high growth rates, low mortalities during larval development and high market value. Although outbreaks of RGNNV, the most common NNV genotype in the Mediterranean Sea, have been detected in wild and farmed shi drums, little is known about host–virus interactions, clinical signs, mortality rates and viral load in this species. In this framework, we have evaluated the mortality rates, the signs of the VER disease including behaviour, histopathological alterations in the brain and retina and the rescue of infective particles in shi drums after infection with the four NNV genotypes (RGNNV, SJNNV, BFNNV and TPNNV). We found that all of the genotypes produce mortalities and analogous time-lapses between the first signs of disease and mortalities. However, infective particles were only recovered from RGNNV-, BFNNV- and TPNNV-infected specimens. Interestingly, clinical signs and histopathological lesions in the brain and retina were different depending on the genotype used.NODAFISHSI202320232021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/313901https://doi.org/10.1016/j.aquaculture.2021.736777reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCentro Oceanográfico de Murciahttps://www.sciencedirect.com/science/article/abs/pii/S0044848621004397?via%3Dihubinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3139012026-05-22T06:33:51Z
dc.title.none.fl_str_mv Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
title Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
spellingShingle Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
Chaves-Pozo, Elena
Betanodavirus
Centro Oceanográfico de Murcia
Acuicultura
Mediterranean fish
Viral diseases
Clinical signs
Viral load
Shi drum
Mortalities
fish
genotypes
cytology
histology
brain
title_short Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
title_full Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
title_fullStr Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
title_full_unstemmed Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
title_sort Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
dc.creator.none.fl_str_mv Chaves-Pozo, Elena
Arizcun, Marta
Cuesta, Alberto
author Chaves-Pozo, Elena
author_facet Chaves-Pozo, Elena
Arizcun, Marta
Cuesta, Alberto
author_role author
author2 Arizcun, Marta
Cuesta, Alberto
author2_role author
author
dc.subject.none.fl_str_mv Betanodavirus
Centro Oceanográfico de Murcia
Acuicultura
Mediterranean fish
Viral diseases
Clinical signs
Viral load
Shi drum
Mortalities
fish
genotypes
cytology
histology
brain
topic Betanodavirus
Centro Oceanográfico de Murcia
Acuicultura
Mediterranean fish
Viral diseases
Clinical signs
Viral load
Shi drum
Mortalities
fish
genotypes
cytology
histology
brain
description Betanodavirus (NNV), the causative agent of viral retinopathy and encephalopathy (VER) disease in fish, is the greatest viral threat for aquaculture growth and diversification in the Mediterranean area, where several genotypes and reassortants have been described. The shi drum (Umbrina cirrosa) is an excellent candidate for marine aquaculture diversification in the Mediterranean area, as this species is easily adapted to culture conditions and shows high growth rates, low mortalities during larval development and high market value. Although outbreaks of RGNNV, the most common NNV genotype in the Mediterranean Sea, have been detected in wild and farmed shi drums, little is known about host–virus interactions, clinical signs, mortality rates and viral load in this species. In this framework, we have evaluated the mortality rates, the signs of the VER disease including behaviour, histopathological alterations in the brain and retina and the rescue of infective particles in shi drums after infection with the four NNV genotypes (RGNNV, SJNNV, BFNNV and TPNNV). We found that all of the genotypes produce mortalities and analogous time-lapses between the first signs of disease and mortalities. However, infective particles were only recovered from RGNNV-, BFNNV- and TPNNV-infected specimens. Interestingly, clinical signs and histopathological lesions in the brain and retina were different depending on the genotype used.
publishDate 2021
dc.date.none.fl_str_mv 2021
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/313901
url http://hdl.handle.net/10261/313901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Centro Oceanográfico de Murcia
https://www.sciencedirect.com/science/article/abs/pii/S0044848621004397?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv https://doi.org/10.1016/j.aquaculture.2021.736777
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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