Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation
Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce t...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:303476 |
| Acceso en línea: | https://ddd.uab.cat/record/303476 https://dx.doi.org/urn:doi:10.1371/journal.pone.0285917 |
| Access Level: | acceso abierto |
| Palabra clave: | Adult Cohort Studies Humans Latent Tuberculosis Prospective Studies Tuberculosis Tuberculosis, Pulmonary |
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Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigationA prospective multicentre cohort studyPérez-Recio, SandraGrijota-Camino, Maria D.|||0000-0001-7729-6864Anibarro, Luis|||0000-0001-8790-6320Rabuñal, Ramón|||0000-0001-5106-5005Sabria, JosefinaGijón-Vidaurreta, PalomaPomar, Virginia|||0000-0002-8473-5834García-Gasalla, Mercedes|||0000-0002-9842-6768Domínguez-Castellano, Ángel M.Trigo-Daporta, Matilde|||0000-0001-7006-2854Santos, María JesúsCebollero, AlbaRodríguez, SaraMoga, Esther|||0000-0003-4264-6910Penas-Truque, AntónMartos, CarmenRuiz-Serrano, María JesúsGarcia-De-Cara, Erika InésAlcaide, Fernando|||0000-0002-4097-1499Santin, M.AdultCohort StudiesHumansLatent TuberculosisProspective StudiesTuberculosisTuberculosis, PulmonaryInterferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/303476https://dx.doi.org/urn:doi:10.1371/journal.pone.0285917reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3034762026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation A prospective multicentre cohort study |
| title |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| spellingShingle |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation Pérez-Recio, Sandra Adult Cohort Studies Humans Latent Tuberculosis Prospective Studies Tuberculosis Tuberculosis, Pulmonary |
| title_short |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| title_full |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| title_fullStr |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| title_full_unstemmed |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| title_sort |
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation |
| dc.creator.none.fl_str_mv |
Pérez-Recio, Sandra Grijota-Camino, Maria D.|||0000-0001-7729-6864 Anibarro, Luis|||0000-0001-8790-6320 Rabuñal, Ramón|||0000-0001-5106-5005 Sabria, Josefina Gijón-Vidaurreta, Paloma Pomar, Virginia|||0000-0002-8473-5834 García-Gasalla, Mercedes|||0000-0002-9842-6768 Domínguez-Castellano, Ángel M. Trigo-Daporta, Matilde|||0000-0001-7006-2854 Santos, María Jesús Cebollero, Alba Rodríguez, Sara Moga, Esther|||0000-0003-4264-6910 Penas-Truque, Antón Martos, Carmen Ruiz-Serrano, María Jesús Garcia-De-Cara, Erika Inés Alcaide, Fernando|||0000-0002-4097-1499 Santin, M. |
| author |
Pérez-Recio, Sandra |
| author_facet |
Pérez-Recio, Sandra Grijota-Camino, Maria D.|||0000-0001-7729-6864 Anibarro, Luis|||0000-0001-8790-6320 Rabuñal, Ramón|||0000-0001-5106-5005 Sabria, Josefina Gijón-Vidaurreta, Paloma Pomar, Virginia|||0000-0002-8473-5834 García-Gasalla, Mercedes|||0000-0002-9842-6768 Domínguez-Castellano, Ángel M. Trigo-Daporta, Matilde|||0000-0001-7006-2854 Santos, María Jesús Cebollero, Alba Rodríguez, Sara Moga, Esther|||0000-0003-4264-6910 Penas-Truque, Antón Martos, Carmen Ruiz-Serrano, María Jesús Garcia-De-Cara, Erika Inés Alcaide, Fernando|||0000-0002-4097-1499 Santin, M. |
| author_role |
author |
| author2 |
Grijota-Camino, Maria D.|||0000-0001-7729-6864 Anibarro, Luis|||0000-0001-8790-6320 Rabuñal, Ramón|||0000-0001-5106-5005 Sabria, Josefina Gijón-Vidaurreta, Paloma Pomar, Virginia|||0000-0002-8473-5834 García-Gasalla, Mercedes|||0000-0002-9842-6768 Domínguez-Castellano, Ángel M. Trigo-Daporta, Matilde|||0000-0001-7006-2854 Santos, María Jesús Cebollero, Alba Rodríguez, Sara Moga, Esther|||0000-0003-4264-6910 Penas-Truque, Antón Martos, Carmen Ruiz-Serrano, María Jesús Garcia-De-Cara, Erika Inés Alcaide, Fernando|||0000-0002-4097-1499 Santin, M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Adult Cohort Studies Humans Latent Tuberculosis Prospective Studies Tuberculosis Tuberculosis, Pulmonary |
| topic |
Adult Cohort Studies Humans Latent Tuberculosis Prospective Studies Tuberculosis Tuberculosis, Pulmonary |
| description |
Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/303476 https://dx.doi.org/urn:doi:10.1371/journal.pone.0285917 |
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https://ddd.uab.cat/record/303476 https://dx.doi.org/urn:doi:10.1371/journal.pone.0285917 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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