Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation

Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce t...

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Detalhes bibliográficos
Autores: Pérez-Recio, Sandra, Grijota-Camino, Maria D.|||0000-0001-7729-6864, Anibarro, Luis|||0000-0001-8790-6320, Rabuñal, Ramón|||0000-0001-5106-5005, Sabria, Josefina, Gijón-Vidaurreta, Paloma, Pomar, Virginia|||0000-0002-8473-5834, García-Gasalla, Mercedes|||0000-0002-9842-6768, Domínguez-Castellano, Ángel M., Trigo-Daporta, Matilde|||0000-0001-7006-2854, Santos, María Jesús, Cebollero, Alba, Rodríguez, Sara, Moga, Esther|||0000-0003-4264-6910, Penas-Truque, Antón, Martos, Carmen, Ruiz-Serrano, María Jesús, Garcia-De-Cara, Erika Inés, Alcaide, Fernando|||0000-0002-4097-1499, Santin, M.
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:303476
Acesso em linha:https://ddd.uab.cat/record/303476
https://dx.doi.org/urn:doi:10.1371/journal.pone.0285917
Access Level:acceso abierto
Palavra-chave:Adult
Cohort Studies
Humans
Latent Tuberculosis
Prospective Studies
Tuberculosis
Tuberculosis, Pulmonary
Descrição
Resumo:Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.

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