Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interfer...

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Detalles Bibliográficos
Autores: Pérez-Recio, Sandra, Pallarès, Natàlia, Grijota-Camino, Maria D.|||0000-0001-7729-6864, Sánchez Montalvá, Adrián|||0000-0002-2194-5447, Barcia, Laura, Campos-Gutiérrez, Silvia, Pomar, Virginia|||0000-0002-8473-5834, Rabuñal-Rey, Ramón, Balcells, María Elvira|||0000-0002-7223-9665, Gazel, Denzil, Montiel, Natalia|||0000-0003-2503-3960, Vicente, Diego|||0000-0003-3553-4312, Goić-Barišić, Ivana, Schön, Thomas, Paues, Jakob, Mareković, Ivana, Cacho-Calvo, Juana, Barac, Aleksandra, Goletti, Delia|||0000-0001-8360-4376, García-Gasalla, Mercedes|||0000-0002-9842-6768, Barcala, José María, Tórtola Fernández, María Teresa|||0000-0002-9188-298X, Anibarro, Luis|||0000-0001-8790-6320, Suárez-Toste, Isabel, Moga, Esther|||0000-0003-4264-6910, Gude-González, María José, Naves, Rodrigo, Karsligil, Tekin, Martin-Peñaranda, Tania|||0000-0002-8727-4308, Stevanovic, Goran, Trigo, Matilde, Rubio, Verónica, Karaoǧlan, Ilkay, Bayram, Nazan, Alcaide, Fernando|||0000-0002-4097-1499, Tebé, Cristian|||0000-0003-2320-1385, Santin, Miguel|||0000-0002-8474-3543
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:264458
Acceso en línea:https://ddd.uab.cat/record/264458
https://dx.doi.org/urn:doi:10.1128/Spectrum.00972-21
Access Level:acceso abierto
Palabra clave:QuantiFERON-TB gold plus
Diagnosis
Latent tuberculosis infection
Tuberculosis-specific CD8 T cells
Descripción
Sumario:We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value.0.6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of.0.6 IU_ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of.0.6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.

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