Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease
A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroi...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/8353 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/8353 |
| Access Level: | acceso abierto |
| Palabra clave: | 617.736 617.723 617.735 616.894-053.9 Alzheimer’s Family history ApoE ε4 AMD Choroid Foveal avascular zone Hard drusen Retina OCT OCTA Neurociencias (Medicina) Oftalmología 2490 Neurociencias 3201.09 Oftalmología |
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Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s DiseaseLópez Cuenca, InésHoz Montañana, María Rosa DeAlcántara Rey, CeliaGarcía Martín, Elena SalobrarElvira Hurtado, LorenaFernández Albarral, JoséBarabash Bustelo, AnaRamírez Toraño, FedericoDe Frutos Lucas, JaisalmerSalazar Corral, Juan JoséRamírez Sebastián, Ana IsabelRamírez Sebastián, José Manuel617.736617.723617.735616.894-053.9Alzheimer’sFamily historyApoE ε4AMDChoroidFoveal avascular zoneHard drusenRetinaOCTOCTANeurociencias (Medicina)Oftalmología2490 Neurociencias3201.09 OftalmologíaA family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.MDPIUniversidad Complutense de Madrid20212021-06-0220212021-06-02journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8353reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/83532026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| title |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| spellingShingle |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease López Cuenca, Inés 617.736 617.723 617.735 616.894-053.9 Alzheimer’s Family history ApoE ε4 AMD Choroid Foveal avascular zone Hard drusen Retina OCT OCTA Neurociencias (Medicina) Oftalmología 2490 Neurociencias 3201.09 Oftalmología |
| title_short |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| title_full |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| title_fullStr |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| title_full_unstemmed |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| title_sort |
Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease |
| dc.creator.none.fl_str_mv |
López Cuenca, Inés Hoz Montañana, María Rosa De Alcántara Rey, Celia García Martín, Elena Salobrar Elvira Hurtado, Lorena Fernández Albarral, José Barabash Bustelo, Ana Ramírez Toraño, Federico De Frutos Lucas, Jaisalmer Salazar Corral, Juan José Ramírez Sebastián, Ana Isabel Ramírez Sebastián, José Manuel |
| author |
López Cuenca, Inés |
| author_facet |
López Cuenca, Inés Hoz Montañana, María Rosa De Alcántara Rey, Celia García Martín, Elena Salobrar Elvira Hurtado, Lorena Fernández Albarral, José Barabash Bustelo, Ana Ramírez Toraño, Federico De Frutos Lucas, Jaisalmer Salazar Corral, Juan José Ramírez Sebastián, Ana Isabel Ramírez Sebastián, José Manuel |
| author_role |
author |
| author2 |
Hoz Montañana, María Rosa De Alcántara Rey, Celia García Martín, Elena Salobrar Elvira Hurtado, Lorena Fernández Albarral, José Barabash Bustelo, Ana Ramírez Toraño, Federico De Frutos Lucas, Jaisalmer Salazar Corral, Juan José Ramírez Sebastián, Ana Isabel Ramírez Sebastián, José Manuel |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
617.736 617.723 617.735 616.894-053.9 Alzheimer’s Family history ApoE ε4 AMD Choroid Foveal avascular zone Hard drusen Retina OCT OCTA Neurociencias (Medicina) Oftalmología 2490 Neurociencias 3201.09 Oftalmología |
| topic |
617.736 617.723 617.735 616.894-053.9 Alzheimer’s Family history ApoE ε4 AMD Choroid Foveal avascular zone Hard drusen Retina OCT OCTA Neurociencias (Medicina) Oftalmología 2490 Neurociencias 3201.09 Oftalmología |
| description |
A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-06-02 2021 2021-06-02 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/8353 |
| url |
https://hdl.handle.net/20.500.14352/8353 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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