Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice

Obesity has reached pandemic proportions worldwide and continues to increase alarmingly, making it urgent to understand the molecular mechanisms that regulate energy metabolism, as well as novel signals secreted by adipose tissue under both physiological and pathological conditions. Recently, extrac...

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Detalhes bibliográficos
Autor: Lago Baameiro, Nerea
Formato: tesis doctoral
Fecha de publicación:2025
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::2826055c0e418f477681d97ba1c5a2b3
Acesso em linha:https://hdl.handle.net/10347/41590
Access Level:acceso abierto
Palavra-chave:Obesity
extracellular vesicle
diabetes
fatty liver
adipose tissue
241104 Fisiología endocrina
320502 Endocrinología
320610 Enfermedades de la nutrición
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spelling Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practiceLago Baameiro, NereaObesityextracellular vesiclediabetesfatty liveradipose tissue241104 Fisiología endocrina320502 Endocrinología320610 Enfermedades de la nutriciónObesity has reached pandemic proportions worldwide and continues to increase alarmingly, making it urgent to understand the molecular mechanisms that regulate energy metabolism, as well as novel signals secreted by adipose tissue under both physiological and pathological conditions. Recently, extracellular vesicles (EVs) have emerged as key mediators of tissue-totissue communication, transporting RNA, proteins and lipids that influence inflammation, metabolism and other cellular functions. This thesis investigates the role of EVs in obesity, focusing on how vesicles secreted by different tissues (adipocytes, hepatocytes, macrophages) contribute to metabolic alterations such as insulin resistance and inflammation. Through in vitro and in vivo experimental models, the composition and functional effects of EVs have been analysed using advanced isolation and proteomic analysis techniques.Pardo Pérez, MaríaUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)Csanueva Freijo, Felipe20252025-01-0120252025-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10347/41590reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::2826055c0e418f477681d97ba1c5a2b32026-06-15T12:47:27Z
dc.title.none.fl_str_mv Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
title Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
spellingShingle Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
Lago Baameiro, Nerea
Obesity
extracellular vesicle
diabetes
fatty liver
adipose tissue
241104 Fisiología endocrina
320502 Endocrinología
320610 Enfermedades de la nutrición
title_short Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
title_full Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
title_fullStr Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
title_full_unstemmed Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
title_sort Study of Extracellular Vesicles in inter-tissue communication in obesity: Functional analysis and identification of circulating vesicular biomarkers for clinical practice
dc.creator.none.fl_str_mv Lago Baameiro, Nerea
author Lago Baameiro, Nerea
author_facet Lago Baameiro, Nerea
author_role author
dc.contributor.none.fl_str_mv Pardo Pérez, María
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
Csanueva Freijo, Felipe
dc.subject.none.fl_str_mv Obesity
extracellular vesicle
diabetes
fatty liver
adipose tissue
241104 Fisiología endocrina
320502 Endocrinología
320610 Enfermedades de la nutrición
topic Obesity
extracellular vesicle
diabetes
fatty liver
adipose tissue
241104 Fisiología endocrina
320502 Endocrinología
320610 Enfermedades de la nutrición
description Obesity has reached pandemic proportions worldwide and continues to increase alarmingly, making it urgent to understand the molecular mechanisms that regulate energy metabolism, as well as novel signals secreted by adipose tissue under both physiological and pathological conditions. Recently, extracellular vesicles (EVs) have emerged as key mediators of tissue-totissue communication, transporting RNA, proteins and lipids that influence inflammation, metabolism and other cellular functions. This thesis investigates the role of EVs in obesity, focusing on how vesicles secreted by different tissues (adipocytes, hepatocytes, macrophages) contribute to metabolic alterations such as insulin resistance and inflammation. Through in vitro and in vivo experimental models, the composition and functional effects of EVs have been analysed using advanced isolation and proteomic analysis techniques.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/41590
url https://hdl.handle.net/10347/41590
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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