Gut Microbiome Proteomics in Food Allergies

20 pages, 2 figures, 1 table.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

Detalhes bibliográficos
Autores: Abril, Ana G., Carrera, Mónica, Sánchez-Pérez, Ángeles, Villa, Tomás G.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/348645
Acesso em linha:http://hdl.handle.net/10261/348645
Access Level:acceso abierto
Palavra-chave:Gastrointestinal track
Microbiota
Mass spectrometry
Metaproteomics
Proteomics
Food allergies
proteomics
food allergies
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spelling Gut Microbiome Proteomics in Food AllergiesAbril, Ana G.Carrera, MónicaSánchez-Pérez, ÁngelesVilla, Tomás G.Gastrointestinal trackMicrobiotaMass spectrometryMetaproteomicsProteomicsFood allergiesproteomicsfood allergies20 pages, 2 figures, 1 table.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseFood allergies (FA) have dramatically increased in recent years, particularly in developed countries. It is currently well-established that food tolerance requires the strict maintenance of a specific microbial consortium in the gastrointestinal (GI) tract microbiome as alterations in the gut microbiota can lead to dysbiosis, causing inflammation and pathogenic intestinal conditions that result in the development of FA. Although there is currently not enough knowledge to fully understand how the interactions between gut microbiota, host responses and the environment cause food allergies, recent advances in ‘-omics’ technologies (i.e., proteomics, genomics, metabolomics) and in approaches involving systems biology suggest future headways that would finally allow the scientific understanding of the relationship between gut microbiome and FA. This review summarizes the current knowledge in the field of FA and insights into the future advances that will be achieved by applying proteomic techniques to study the GI tract microbiome in the field of FA and their medical treatment. Metaproteomics, a proteomics experimental approach of great interest in the study of GI tract microbiota, aims to analyze and identify all the proteins in complex environmental microbial communities; with shotgun proteomics, which uses liquid chromatography (LC) for separation and tandem mass spectrometry (MS/MS) for analysis, as it is the most promising technique in this fieldA.G.A. thanks the USC for his “Convocatoria de Recualificación do Sistema Universitario Español-Margarita Salas” postdoc grant under the “Plan de Recuperación Transformación” program funded by the Spanish Ministry of Universities with European Union’s NextGeneration EU funds. This work was funded by the Spanish MCIN/AEI PID2019-103845RB-C21 projectPeer reviewedMultidisciplinary Digital Publishing InstituteUniversidad de Santiago de CompostelaMinisterio de Universidades (España)European CommissionMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/348645reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103845RB-C21The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/ijms24032234https://doi.org/10.3390/ijms24032234Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3486452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gut Microbiome Proteomics in Food Allergies
title Gut Microbiome Proteomics in Food Allergies
spellingShingle Gut Microbiome Proteomics in Food Allergies
Abril, Ana G.
Gastrointestinal track
Microbiota
Mass spectrometry
Metaproteomics
Proteomics
Food allergies
proteomics
food allergies
title_short Gut Microbiome Proteomics in Food Allergies
title_full Gut Microbiome Proteomics in Food Allergies
title_fullStr Gut Microbiome Proteomics in Food Allergies
title_full_unstemmed Gut Microbiome Proteomics in Food Allergies
title_sort Gut Microbiome Proteomics in Food Allergies
dc.creator.none.fl_str_mv Abril, Ana G.
Carrera, Mónica
Sánchez-Pérez, Ángeles
Villa, Tomás G.
author Abril, Ana G.
author_facet Abril, Ana G.
Carrera, Mónica
Sánchez-Pérez, Ángeles
Villa, Tomás G.
author_role author
author2 Carrera, Mónica
Sánchez-Pérez, Ángeles
Villa, Tomás G.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Santiago de Compostela
Ministerio de Universidades (España)
European Commission
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gastrointestinal track
Microbiota
Mass spectrometry
Metaproteomics
Proteomics
Food allergies
proteomics
food allergies
topic Gastrointestinal track
Microbiota
Mass spectrometry
Metaproteomics
Proteomics
Food allergies
proteomics
food allergies
description 20 pages, 2 figures, 1 table.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/348645
url http://hdl.handle.net/10261/348645
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103845RB-C21
The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/ijms24032234
https://doi.org/10.3390/ijms24032234
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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