Engineering the T6SS of Pseudomonas for targeted delivery of antibacterial and antifungal effectors

Bacteria employ diverse molecular systems, such as the type VI secretion system (T6SS) to outcompete other microorganisms and adapt to ecological niches. The T6SS is a versatile nanomachine capable of delivering toxic effectors into neighboring cells, providing advantages in bacterial interactions....

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Bibliographic Details
Authors: Pérez-Lorente, Alicia Isabel, Araujo-Garrido, Mario, de Vicente, Antonio, Romero, Diego, Molina-Santiago, Carlos
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/388155
Online Access:http://hdl.handle.net/10261/388155
https://api.elsevier.com/content/abstract/scopus_id/105001734033
Access Level:Open access
Keyword:Pseudomonas putida
Antibacterial activity
Antifungal activity
Effectors
Genetic engineering
T6SS
Description
Summary:Bacteria employ diverse molecular systems, such as the type VI secretion system (T6SS) to outcompete other microorganisms and adapt to ecological niches. The T6SS is a versatile nanomachine capable of delivering toxic effectors into neighboring cells, providing advantages in bacterial interactions. In recent years, T6SSs have been proposed as promising tools for engineering selective antimicrobial platforms.