Age-related differences in cardiogenic shock secondary to Takotsubo syndrome
Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:320280 |
| Acceso en línea: | https://ddd.uab.cat/record/320280 https://dx.doi.org/urn:doi:10.1111/eci.70119 |
| Access Level: | acceso abierto |
| Palabra clave: | Age- related differences Cardiogenic shock Heart failure Left ventricular dysfunction Stresscardiomyopathy Takotsubo |
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Age-related differences in cardiogenic shock secondary to Takotsubo syndromeTomasino, Marco|||0000-0003-1989-4342Vazirani Ballesteros, Ravi|||0000-0002-7337-0593Salamanca, Jorge|||0000-0002-5067-5052Raposeiras-Roubin, Sergio|||0000-0002-6462-4715Fernández-Cordon, Clara|||0000-0002-2492-2873Corbí-Pascual, Miguel|||0000-0001-5923-1290Vedia Cruz, Oscar|||0000-0001-5062-3335Martin-Garcia, Agustin C.|||0000-0001-8662-3791Blanco, Emilia|||0000-0001-6157-679XAlmendro-Delia, Manuel|||0000-0001-7144-4782Piserra López, AlbertoLarre Guerra, Jaime FranciscoGonzalez-Santorum, FranciscoLluch Requerey, Carmen|||0000-0001-8563-2717Guillén Marzo, Marta|||0000-0003-3345-2356Pérez-Castellanos, Alberto|||0000-0002-5879-0012Ridocci-Soriano, FranciscoLópez-Pais, Javier|||0000-0001-5511-5954Andrea-Riba, Rut|||0000-0002-8409-5013Sionis, Alessandro|||0000-0003-0843-9512Nuñez-Gil, Ivan Javier|||0000-0002-1779-3102Uribarri, Aitor|||0000-0002-6911-7480Age- related differencesCardiogenic shockHeart failureLeft ventricular dysfunctionStresscardiomyopathyTakotsuboBackground: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p =.01), have a physical trigger (65% vs. 43% and 49%, p =.04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p =.02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p =.01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p =.15). Older age independently predicted both in-hospital mortality (OR 2.33, 95% CI 1.05-5.17; reference: middle-aged) and 5-year mortality (HR 3.69, 95% CI 1.77-7.67), regardless of shock severity. Conclusions: In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/320280https://dx.doi.org/urn:doi:10.1111/eci.70119reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3202802026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| title |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| spellingShingle |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome Tomasino, Marco|||0000-0003-1989-4342 Age- related differences Cardiogenic shock Heart failure Left ventricular dysfunction Stresscardiomyopathy Takotsubo |
| title_short |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| title_full |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| title_fullStr |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| title_full_unstemmed |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| title_sort |
Age-related differences in cardiogenic shock secondary to Takotsubo syndrome |
| dc.creator.none.fl_str_mv |
Tomasino, Marco|||0000-0003-1989-4342 Vazirani Ballesteros, Ravi|||0000-0002-7337-0593 Salamanca, Jorge|||0000-0002-5067-5052 Raposeiras-Roubin, Sergio|||0000-0002-6462-4715 Fernández-Cordon, Clara|||0000-0002-2492-2873 Corbí-Pascual, Miguel|||0000-0001-5923-1290 Vedia Cruz, Oscar|||0000-0001-5062-3335 Martin-Garcia, Agustin C.|||0000-0001-8662-3791 Blanco, Emilia|||0000-0001-6157-679X Almendro-Delia, Manuel|||0000-0001-7144-4782 Piserra López, Alberto Larre Guerra, Jaime Francisco Gonzalez-Santorum, Francisco Lluch Requerey, Carmen|||0000-0001-8563-2717 Guillén Marzo, Marta|||0000-0003-3345-2356 Pérez-Castellanos, Alberto|||0000-0002-5879-0012 Ridocci-Soriano, Francisco López-Pais, Javier|||0000-0001-5511-5954 Andrea-Riba, Rut|||0000-0002-8409-5013 Sionis, Alessandro|||0000-0003-0843-9512 Nuñez-Gil, Ivan Javier|||0000-0002-1779-3102 Uribarri, Aitor|||0000-0002-6911-7480 |
| author |
Tomasino, Marco|||0000-0003-1989-4342 |
| author_facet |
Tomasino, Marco|||0000-0003-1989-4342 Vazirani Ballesteros, Ravi|||0000-0002-7337-0593 Salamanca, Jorge|||0000-0002-5067-5052 Raposeiras-Roubin, Sergio|||0000-0002-6462-4715 Fernández-Cordon, Clara|||0000-0002-2492-2873 Corbí-Pascual, Miguel|||0000-0001-5923-1290 Vedia Cruz, Oscar|||0000-0001-5062-3335 Martin-Garcia, Agustin C.|||0000-0001-8662-3791 Blanco, Emilia|||0000-0001-6157-679X Almendro-Delia, Manuel|||0000-0001-7144-4782 Piserra López, Alberto Larre Guerra, Jaime Francisco Gonzalez-Santorum, Francisco Lluch Requerey, Carmen|||0000-0001-8563-2717 Guillén Marzo, Marta|||0000-0003-3345-2356 Pérez-Castellanos, Alberto|||0000-0002-5879-0012 Ridocci-Soriano, Francisco López-Pais, Javier|||0000-0001-5511-5954 Andrea-Riba, Rut|||0000-0002-8409-5013 Sionis, Alessandro|||0000-0003-0843-9512 Nuñez-Gil, Ivan Javier|||0000-0002-1779-3102 Uribarri, Aitor|||0000-0002-6911-7480 |
| author_role |
author |
| author2 |
Vazirani Ballesteros, Ravi|||0000-0002-7337-0593 Salamanca, Jorge|||0000-0002-5067-5052 Raposeiras-Roubin, Sergio|||0000-0002-6462-4715 Fernández-Cordon, Clara|||0000-0002-2492-2873 Corbí-Pascual, Miguel|||0000-0001-5923-1290 Vedia Cruz, Oscar|||0000-0001-5062-3335 Martin-Garcia, Agustin C.|||0000-0001-8662-3791 Blanco, Emilia|||0000-0001-6157-679X Almendro-Delia, Manuel|||0000-0001-7144-4782 Piserra López, Alberto Larre Guerra, Jaime Francisco Gonzalez-Santorum, Francisco Lluch Requerey, Carmen|||0000-0001-8563-2717 Guillén Marzo, Marta|||0000-0003-3345-2356 Pérez-Castellanos, Alberto|||0000-0002-5879-0012 Ridocci-Soriano, Francisco López-Pais, Javier|||0000-0001-5511-5954 Andrea-Riba, Rut|||0000-0002-8409-5013 Sionis, Alessandro|||0000-0003-0843-9512 Nuñez-Gil, Ivan Javier|||0000-0002-1779-3102 Uribarri, Aitor|||0000-0002-6911-7480 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Age- related differences Cardiogenic shock Heart failure Left ventricular dysfunction Stresscardiomyopathy Takotsubo |
| topic |
Age- related differences Cardiogenic shock Heart failure Left ventricular dysfunction Stresscardiomyopathy Takotsubo |
| description |
Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p =.01), have a physical trigger (65% vs. 43% and 49%, p =.04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p =.02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p =.01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p =.15). Older age independently predicted both in-hospital mortality (OR 2.33, 95% CI 1.05-5.17; reference: middle-aged) and 5-year mortality (HR 3.69, 95% CI 1.77-7.67), regardless of shock severity. Conclusions: In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/320280 https://dx.doi.org/urn:doi:10.1111/eci.70119 |
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https://ddd.uab.cat/record/320280 https://dx.doi.org/urn:doi:10.1111/eci.70119 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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