Age-related differences in cardiogenic shock secondary to Takotsubo syndrome

Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three...

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Detalles Bibliográficos
Autores: Tomasino, Marco|||0000-0003-1989-4342, Vazirani Ballesteros, Ravi|||0000-0002-7337-0593, Salamanca, Jorge|||0000-0002-5067-5052, Raposeiras-Roubin, Sergio|||0000-0002-6462-4715, Fernández-Cordon, Clara|||0000-0002-2492-2873, Corbí-Pascual, Miguel|||0000-0001-5923-1290, Vedia Cruz, Oscar|||0000-0001-5062-3335, Martin-Garcia, Agustin C.|||0000-0001-8662-3791, Blanco, Emilia|||0000-0001-6157-679X, Almendro-Delia, Manuel|||0000-0001-7144-4782, Piserra López, Alberto, Larre Guerra, Jaime Francisco, Gonzalez-Santorum, Francisco, Lluch Requerey, Carmen|||0000-0001-8563-2717, Guillén Marzo, Marta|||0000-0003-3345-2356, Pérez-Castellanos, Alberto|||0000-0002-5879-0012, Ridocci-Soriano, Francisco, López-Pais, Javier|||0000-0001-5511-5954, Andrea-Riba, Rut|||0000-0002-8409-5013, Sionis, Alessandro|||0000-0003-0843-9512, Nuñez-Gil, Ivan Javier|||0000-0002-1779-3102, Uribarri, Aitor|||0000-0002-6911-7480
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:320280
Acceso en línea:https://ddd.uab.cat/record/320280
https://dx.doi.org/urn:doi:10.1111/eci.70119
Access Level:acceso abierto
Palabra clave:Age- related differences
Cardiogenic shock
Heart failure
Left ventricular dysfunction
Stresscardiomyopathy
Takotsubo
Descripción
Sumario:Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p =.01), have a physical trigger (65% vs. 43% and 49%, p =.04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p =.02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p =.01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p =.15). Older age independently predicted both in-hospital mortality (OR 2.33, 95% CI 1.05-5.17; reference: middle-aged) and 5-year mortality (HR 3.69, 95% CI 1.77-7.67), regardless of shock severity. Conclusions: In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS.

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