Valorization of native grape pomace through vesicular nanocarriers for the enhanced delivery of high-value natural bioactive compounds in green cosmeceutical applications
Agro-industrial by-products such as grape pomace represent a sustainable source of bioactive phenolic compounds; however, their practical application in cosmeceutical formulations is limited by their chemical instability, heterogeneous composition, and low skin bioavailability. Although vesicular na...
| Autores: | , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Recursos: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:dnet:ruidera_____::b89a58e1a98154fb503e526d6f1323a9 |
| Acesso em linha: | https://doi.org/10.1016/j.scp.2026.102435 https://www.sciencedirect.com/science/article/pii/S2352554126001270 https://hdl.handle.net/10578/48542 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cosmeceutical application Grape pomace Phospholipid vesicles Upcycling |
| Resumo: | Agro-industrial by-products such as grape pomace represent a sustainable source of bioactive phenolic compounds; however, their practical application in cosmeceutical formulations is limited by their chemical instability, heterogeneous composition, and low skin bioavailability. Although vesicular nanocarriers have been widely proposed to overcome these limitations, their interaction with complex polyphenolic matrices remains poorly understood, and comparative studies across different vesicle types are still scarce. In this context, the present work tests the hypothesis that the composition and physicochemical properties of vesicular systems differentially modulate the encapsulation efficiency, stability, and biological activity of grape pomace-derived phenolics. Grape pomace extracts from three red grape varieties (Cabernet Sauvignon, Malbec, Tinto de la P´ ampana Blanca) were obtained using a green extraction approach and characterized in terms of yield, total phenolic content and antioxidant capacity. The most promising extract, Tinto de la P´ ampana Blanca, was incorporated into four vesicular systems (liposomes, ethosomes, trans fersomes and Transcutol® P penetration enhancer containing vesicles (PEVs)) which were eval uated in terms of physicochemical properties, encapsulation efficiency and biological performance in keratinocytes under oxidative stress. Results demonstrate that vesicle composition significantly influences both colloidal stability and biological response. |
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