Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe

Background: Within influenza vaccine effectiveness (VE) studies at primary care level with a laboratory-confirmed outcome, clinical case definitions for recruitment of patients can vary. We used the 2022-23 VEBIS primary care European multicentre study end-of-season data to evaluate whether the clin...

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Detalhes bibliográficos
Autores: Maurel, Marine, Mazagatos, Clara, Goerlitz, Luise, Oroszi, Beatrix, Hooiveld, Mariëtte, Machado, Ausenda, Domegan, Lisa, Ilić, Maja, Popescu, Rodica, Sève, Noémie, Martínez-Baz, Iván, Larrauri, Amparo, Buda, Silke, Túri, Gergő, Meijer, Adam, Gomez, Verónica, O'Donnell, Joan, Mlinarić, Ivan, Timnea, Olivia, Diez, Ana Ordax, Dürrwald, Ralf, Horváth, Judit Krisztina, Dijkstra, Frederika, Rodrigues, Ana Paula, McKenna, Adele, Filipović, Sanja Kurečić, Lazar, Mihaela, Kaczmarek, Marlena, Bacci, Sabrina, Kissling, Esther, VEBIS study team
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20371
Acesso em linha:http://hdl.handle.net/20.500.12105/20371
Access Level:acceso abierto
Palavra-chave:Influenza Vaccines
Influenza, Human
Primary Health Care
Vaccine Efficacy
Humans
Adolescent
Europe
Adult
Middle Aged
Female
Aged
Male
Child, Preschool
Child
Young Adult
Case-Control Studies
Infant
Seasons
Infant, Newborn
Vaccination
Respiratory Tract Infections
Descrição
Resumo:Background: Within influenza vaccine effectiveness (VE) studies at primary care level with a laboratory-confirmed outcome, clinical case definitions for recruitment of patients can vary. We used the 2022-23 VEBIS primary care European multicentre study end-of-season data to evaluate whether the clinical case definition affected IVE estimates. Methods: We estimated VE using a multicentre test-negative case-control design. We measured VE against any influenza and influenza (sub)types, by age group (0-14, 15-64, ≥65 years) and by influenza vaccine target group, using logistic regression. We estimated IVE among patients meeting the European Union (EU) acute respiratory infection (ARI) case definition and among those meeting the EU influenza-like illness (ILI) case definition, including only sites providing information on specific symptoms and recruiting patients using an ARI case definition (as the EU ILI case definition is a subset of the EU ARI one). Results: We included 24 319 patients meeting the EU ARI case definition, of whom 21 804 patients (90 %) meet the EU ILI case definition, for the overall pooled VE analysis against any influenza. The overall and influenza (sub)type-specific VE varied by ≤2 % between EU ILI and EU ARI populations. Discussion: Among all analyses, we found similar VE estimates between the EU ILI and EU ARI populations, with few (10%) additional non-ILI ARI patients recruited. These results indicate that VE in the 2022-23 influenza season was not affected by use of a different clinical case definition for recruitment, although we recommend investigating whether this holds true for next seasons.

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