Influenza vaccine effectiveness in Europe: Results from the 2022-2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study

Background: Influenza A(H3N2) viruses dominated early in the 2022-2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test-negative study. Materi...

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Autores: Maurel, Marine, Pozo Sanchez, Francisco, Pérez-Gimeno, Gloria, Buda, Silke, Sève, Noémie, Oroszi, Beatrix, Hooiveld, Mariëtte, Gomez, Verónica, Domegan, Lisa, Martínez-Baz, Iván, Ilić, Maja, Carnahan, AnnaSara, Mihai, Maria Elena, Martínez, Ana, Goerlitz, Luise, Enouf, Vincent, Horváth, Judit Krisztina, Dijkstra, Frederika, Rodrigues, Ana Paula, Bennett, Charlene, Trobajo-Sanmartín, Camino, Mlinarić, Ivan, Latorre-Margalef, Neus, Ivanciuc, Alina, Lopez, Aurora, Dürrwald, Ralf, Falchi, Alessandra, Túri, Gergő, Meijer, Adam, Melo, Aryse, O'Donnell, Joan, Castilla, Jesús, Vučina, Vesna Višekruna, Hagey, Tove Samuelsson, Lazar, Mihaela, Kaczmarek, Marlena, Bacci, Sabrina, Kissling, Esther, VEBIS study team
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/19016
Acceso en línea:http://hdl.handle.net/20.500.12105/19016
Access Level:acceso abierto
Palabra clave:Influenza A virus
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Influenza, Human
Child
Humans
Europe
Influenza A Virus, H3N2 Subtype
Primary Health Care
Vaccine Efficacy
Infant, Newborn
Infant
Child, Preschool
Adolescent
Young Adult
Adult
Middle Aged
Descripción
Sumario:Background: Influenza A(H3N2) viruses dominated early in the 2022-2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test-negative study. Materials and methods: Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression. Results: We included 38 058 patients, of which 3786 were influenza A(H3N2), 1548 influenza A(H1N1)pdm09 and 3275 influenza B cases. Against influenza A(H3N2), VE was 36% (95% CI: 25-45) among all ages and ranged between 30% and 52% by age group and target group. VE against influenza A(H3N2) clade 2b was 38% (95% CI: 25-49). Overall, VE against influenza A(H1N1)pdm09 was 46% (95% CI: 35-56) and ranged between 29% and 59% by age group and target group. VE against influenza A(H1N1)pdm09 clade 5a.2a was 56% (95% CI: 46-65) and 79% (95% CI: 64-88) against clade 5a.2a.1. VE against influenza B was 76% (95% CI: 70-81); overall, 84%, 72% and 71% were among 0-14-year-olds, 15-64-year-olds and those in the influenza vaccination target group, respectively. VE against influenza B with a position 197 mutation of the hemagglutinin (HA) gene was 79% (95% CI: 73-85) and 90% (95% CI: 85-94) without this mutation. Conclusion: The 2022-2023 end-of-season results from the VEBIS network at primary care level showed high VE among children and against influenza B, with lower VE against influenza A(H1N1)pdm09 and A(H3N2).

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