Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease

The current Thesis deals with the searching of biomarkers for an early Alzheimer’s disease diagnosis. The two first chapters have been devoted to the optimization of methods for the determination of several elements by ICP-MS (use of dried blood spot, DBS; and discrete sampling followed to introduct...

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Detalles Bibliográficos
Autor: Chantada Vázquez, María del Pilar
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/19893
Acceso en línea:http://hdl.handle.net/10347/19893
Access Level:acceso abierto
Palabra clave:Materias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masas
Materias::Investigación::23 Química::2301 química analítica ::230199 Proteómica
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spelling Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's DiseaseChantada Vázquez, María del PilarMaterias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masasMaterias::Investigación::23 Química::2301 química analítica ::230199 ProteómicaThe current Thesis deals with the searching of biomarkers for an early Alzheimer’s disease diagnosis. The two first chapters have been devoted to the optimization of methods for the determination of several elements by ICP-MS (use of dried blood spot, DBS; and discrete sampling followed to introduction in ICP-MS). In the second part of this thesis regarding proteomics, several proteins for differentiating three groups of population (healthy people, AD patients, and MCI patients) have been found. In a final chapter, LA conditions have been optimized for the determination of metals in the isoforms of two proteins [Serotransferrin (TRFE) and Keratin type II cytoskeletal 1 (K2C1)] after 2D electrophoresis.Moreda Piñeiro, AntonioBermejo Barrera, PilarUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias e Tecnoloxía20192019-01-0120192019-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/19893reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/198932026-06-15T12:47:27Z
dc.title.none.fl_str_mv Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
title Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
spellingShingle Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
Chantada Vázquez, María del Pilar
Materias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masas
Materias::Investigación::23 Química::2301 química analítica ::230199 Proteómica
title_short Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
title_full Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
title_fullStr Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
title_full_unstemmed Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
title_sort Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
dc.creator.none.fl_str_mv Chantada Vázquez, María del Pilar
author Chantada Vázquez, María del Pilar
author_facet Chantada Vázquez, María del Pilar
author_role author
dc.contributor.none.fl_str_mv Moreda Piñeiro, Antonio
Bermejo Barrera, Pilar
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias e Tecnoloxía
dc.subject.none.fl_str_mv Materias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masas
Materias::Investigación::23 Química::2301 química analítica ::230199 Proteómica
topic Materias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masas
Materias::Investigación::23 Química::2301 química analítica ::230199 Proteómica
description The current Thesis deals with the searching of biomarkers for an early Alzheimer’s disease diagnosis. The two first chapters have been devoted to the optimization of methods for the determination of several elements by ICP-MS (use of dried blood spot, DBS; and discrete sampling followed to introduction in ICP-MS). In the second part of this thesis regarding proteomics, several proteins for differentiating three groups of population (healthy people, AD patients, and MCI patients) have been found. In a final chapter, LA conditions have been optimized for the determination of metals in the isoforms of two proteins [Serotransferrin (TRFE) and Keratin type II cytoskeletal 1 (K2C1)] after 2D electrophoresis.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/19893
url http://hdl.handle.net/10347/19893
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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