Developments on Metallomic and Proteomic strategies for early diagnosis of Alzheimer's Disease
The current Thesis deals with the searching of biomarkers for an early Alzheimer’s disease diagnosis. The two first chapters have been devoted to the optimization of methods for the determination of several elements by ICP-MS (use of dried blood spot, DBS; and discrete sampling followed to introduct...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/19893 |
| Acceso en línea: | http://hdl.handle.net/10347/19893 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::23 Química::2301 química analítica ::230110 Espectroscopia de masas Materias::Investigación::23 Química::2301 química analítica ::230199 Proteómica |
| Sumario: | The current Thesis deals with the searching of biomarkers for an early Alzheimer’s disease diagnosis. The two first chapters have been devoted to the optimization of methods for the determination of several elements by ICP-MS (use of dried blood spot, DBS; and discrete sampling followed to introduction in ICP-MS). In the second part of this thesis regarding proteomics, several proteins for differentiating three groups of population (healthy people, AD patients, and MCI patients) have been found. In a final chapter, LA conditions have been optimized for the determination of metals in the isoforms of two proteins [Serotransferrin (TRFE) and Keratin type II cytoskeletal 1 (K2C1)] after 2D electrophoresis. |
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