Intramolecular Hydrogen-Bond Activation: Strategies, Benefits, and Influence in Catalysis

The activation of molecules through intramolecular hydrogen-bond formation to promote chemical reactions appears as a suitable strategy in organic synthesis, especially for the preparation of chiral compounds under metal and organocatalytic conditions. The use of this interaction has enabled reactiv...

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Detalles Bibliográficos
Autores: Guerrero-Corella, Andrea, Fraile Carrasco, Alberto, Alemán Lara, José Julián
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/702717
Acceso en línea:http://hdl.handle.net/10486/702717
https://dx.doi.org/10.1021/acsorginorgau.1c00053
Access Level:acceso abierto
Palabra clave:Intramolecular activation,
Hydrogen bonding
Organocatalysis
Metal catalysis
Bifunctional catalysis
Asymmetric synthesis
Química
Descripción
Sumario:The activation of molecules through intramolecular hydrogen-bond formation to promote chemical reactions appears as a suitable strategy in organic synthesis, especially for the preparation of chiral compounds under metal and organocatalytic conditions. The use of this interaction has enabled reactivity enhancement of reagents, as well as stabilization of the chemical species and enantiocontrol of the processes