Synergistic catalysis: Asymmetric synthesis of cyclopentanes bearing four stereogenic centers

We present a formal [3+2] cycloaddition based on synergistic catalysis. Vinylcyclopropanes derived from cyanoesters react with enals by dual activation using palladium(0) and secondary amines to form the corresponding cyclopentanes in good yields and stereoselectivities.

Detalles Bibliográficos
Autores: Zhang, Kaiheng, Meazza, Marta, Izaga, Anabel, Contamine, Clotilde, Gimeno, M. Concepción, Herrera, Raquel P., Rios, Ramon
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/155869
Acceso en línea:http://hdl.handle.net/10261/155869
Access Level:acceso abierto
Palabra clave:Synergistic catalysis
Organocatalysis
Cyclopentanes
Cycloaddition
Asymmetric synthesis
Descripción
Sumario:We present a formal [3+2] cycloaddition based on synergistic catalysis. Vinylcyclopropanes derived from cyanoesters react with enals by dual activation using palladium(0) and secondary amines to form the corresponding cyclopentanes in good yields and stereoselectivities.

Similares en LA Referencia