Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture

In primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokin...

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Detalles Bibliográficos
Autores: Miralpeix, Montserrat, Decaux, Jean-François, Kahn, Axel, Bartrons Bach, Ramon
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1991
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/134640
Acceso en línea:https://hdl.handle.net/2445/134640
Access Level:acceso abierto
Palabra clave:Micro RNAs
Isoenzims
Genètica
Fetge
Enzimologia
Biosíntesi
Farmacologia
MicroRNAs
Isoenzymes
Genetics
Liver
Enzymology
Biosynthesis
Pharmacology
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spelling Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary cultureMiralpeix, MontserratDecaux, Jean-FrançoisKahn, AxelBartrons Bach, RamonMicro RNAsIsoenzimsGenèticaFetgeEnzimologiaBiosíntesiFarmacologiaMicroRNAsIsoenzymesGeneticsLiverEnzymologyBiosynthesisPharmacologyIn primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokinase gene expression. An analogue of cAMP, 8-(4-chlorophenylthio)-cAMP, inhibited the production of L-type pyruvate kinase and glucokinase mRNAs in the presence of glucose plus vanadate.American Diabetes Association1991info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/134640Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.2337/diab.40.4.462Diabetes, 1991, vol. 40, num. 4, p. 462-464https://doi.org/10.2337/diab.40.4.462cc-by-nc-nd (c) American Diabetes Association, 1991http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1346402026-05-27T06:46:51Z
dc.title.none.fl_str_mv Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
title Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
spellingShingle Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
Miralpeix, Montserrat
Micro RNAs
Isoenzims
Genètica
Fetge
Enzimologia
Biosíntesi
Farmacologia
MicroRNAs
Isoenzymes
Genetics
Liver
Enzymology
Biosynthesis
Pharmacology
title_short Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
title_full Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
title_fullStr Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
title_full_unstemmed Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
title_sort Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
dc.creator.none.fl_str_mv Miralpeix, Montserrat
Decaux, Jean-François
Kahn, Axel
Bartrons Bach, Ramon
author Miralpeix, Montserrat
author_facet Miralpeix, Montserrat
Decaux, Jean-François
Kahn, Axel
Bartrons Bach, Ramon
author_role author
author2 Decaux, Jean-François
Kahn, Axel
Bartrons Bach, Ramon
author2_role author
author
author
dc.subject.none.fl_str_mv Micro RNAs
Isoenzims
Genètica
Fetge
Enzimologia
Biosíntesi
Farmacologia
MicroRNAs
Isoenzymes
Genetics
Liver
Enzymology
Biosynthesis
Pharmacology
topic Micro RNAs
Isoenzims
Genètica
Fetge
Enzimologia
Biosíntesi
Farmacologia
MicroRNAs
Isoenzymes
Genetics
Liver
Enzymology
Biosynthesis
Pharmacology
description In primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokinase gene expression. An analogue of cAMP, 8-(4-chlorophenylthio)-cAMP, inhibited the production of L-type pyruvate kinase and glucokinase mRNAs in the presence of glucose plus vanadate.
publishDate 1991
dc.date.none.fl_str_mv 1991
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134640
url https://hdl.handle.net/2445/134640
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2337/diab.40.4.462
Diabetes, 1991, vol. 40, num. 4, p. 462-464
https://doi.org/10.2337/diab.40.4.462
dc.rights.none.fl_str_mv cc-by-nc-nd (c) American Diabetes Association, 1991
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) American Diabetes Association, 1991
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Diabetes Association
publisher.none.fl_str_mv American Diabetes Association
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405730975514624
score 15,300719

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