Vanadate increases L-type pyruvate kinase mRNAs level in adult rat hepatocytes in primary culture
In primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokin...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 1991 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/134640 |
| Acesso em linha: | https://hdl.handle.net/2445/134640 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Micro RNAs Isoenzims Genètica Fetge Enzimologia Biosíntesi Farmacologia MicroRNAs Isoenzymes Genetics Liver Enzymology Biosynthesis Pharmacology |
| Resumo: | In primary culture of adult rat hepatocytes, vanadate in the presence of glucose stimulates the expression of the liver (L-type) pyruvate kinase gene. Glucose by itself was inactive, and vanadate, like insulin, was also inefficient in the absence of glucose. Similar results were obtained on glucokinase gene expression. An analogue of cAMP, 8-(4-chlorophenylthio)-cAMP, inhibited the production of L-type pyruvate kinase and glucokinase mRNAs in the presence of glucose plus vanadate. |
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