The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study

Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish mult...

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Autores: Flores, José Carlos, Gracia Lavedan, Esther, Benavente, Yolanda, Amiano, Pilar, Romaguera, Dora, Costas, Laura, Robles, Claudia, González Barca, Eva, Banda, Esmeralda de la, Alonso Sanz, Esther, Aymerich Gregorio, Marta, Campo Güerri, Elias, Dierssen Sotos, Trinidad, Marcos Gragera, Rafael, Rodriguez Suarez, Marta María, Solans, Marta, Gimeno Vázquez, Eva, Garcia Martin, Paloma, Aragonès Sanz, Núria, Shivappa, Nitin, Hébert, James R., Pollán, Marina, Kogevinas, Manolis, Sanjosé Llongueras, Silvia de, Castaño-Vinyals, Gemma, Casabonne, Delphine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/148017
Acceso en línea:https://hdl.handle.net/2445/148017
Access Level:acceso abierto
Palabra clave:Leucèmia limfocítica crònica
Càncer
Chronic lymphocytic leukemia
Cancer
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spelling The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain StudyFlores, José CarlosGracia Lavedan, EstherBenavente, YolandaAmiano, PilarRomaguera, DoraCostas, LauraRobles, ClaudiaGonzález Barca, EvaBanda, Esmeralda de laAlonso Sanz, EstherAymerich Gregorio, MartaCampo Güerri, EliasDierssen Sotos, TrinidadMarcos Gragera, RafaelRodriguez Suarez, Marta MaríaSolans, MartaGimeno Vázquez, EvaGarcia Martin, PalomaAragonès Sanz, NúriaShivappa, NitinHébert, James R.Pollán, MarinaKogevinas, ManolisSanjosé Llongueras, Silvia deCastaño-Vinyals, GemmaCasabonne, DelphineLeucèmia limfocítica crònicaCàncerChronic lymphocytic leukemiaCancerChronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.MDPI AG2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/148017Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu12010048Nutrients, 2019, vol. 12, num. 1https://doi.org/10.3390/nu12010048cc by (c) Flores et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1480172026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
title The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
spellingShingle The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
Flores, José Carlos
Leucèmia limfocítica crònica
Càncer
Chronic lymphocytic leukemia
Cancer
title_short The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
title_full The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
title_fullStr The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
title_full_unstemmed The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
title_sort The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
dc.creator.none.fl_str_mv Flores, José Carlos
Gracia Lavedan, Esther
Benavente, Yolanda
Amiano, Pilar
Romaguera, Dora
Costas, Laura
Robles, Claudia
González Barca, Eva
Banda, Esmeralda de la
Alonso Sanz, Esther
Aymerich Gregorio, Marta
Campo Güerri, Elias
Dierssen Sotos, Trinidad
Marcos Gragera, Rafael
Rodriguez Suarez, Marta María
Solans, Marta
Gimeno Vázquez, Eva
Garcia Martin, Paloma
Aragonès Sanz, Núria
Shivappa, Nitin
Hébert, James R.
Pollán, Marina
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Castaño-Vinyals, Gemma
Casabonne, Delphine
author Flores, José Carlos
author_facet Flores, José Carlos
Gracia Lavedan, Esther
Benavente, Yolanda
Amiano, Pilar
Romaguera, Dora
Costas, Laura
Robles, Claudia
González Barca, Eva
Banda, Esmeralda de la
Alonso Sanz, Esther
Aymerich Gregorio, Marta
Campo Güerri, Elias
Dierssen Sotos, Trinidad
Marcos Gragera, Rafael
Rodriguez Suarez, Marta María
Solans, Marta
Gimeno Vázquez, Eva
Garcia Martin, Paloma
Aragonès Sanz, Núria
Shivappa, Nitin
Hébert, James R.
Pollán, Marina
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Castaño-Vinyals, Gemma
Casabonne, Delphine
author_role author
author2 Gracia Lavedan, Esther
Benavente, Yolanda
Amiano, Pilar
Romaguera, Dora
Costas, Laura
Robles, Claudia
González Barca, Eva
Banda, Esmeralda de la
Alonso Sanz, Esther
Aymerich Gregorio, Marta
Campo Güerri, Elias
Dierssen Sotos, Trinidad
Marcos Gragera, Rafael
Rodriguez Suarez, Marta María
Solans, Marta
Gimeno Vázquez, Eva
Garcia Martin, Paloma
Aragonès Sanz, Núria
Shivappa, Nitin
Hébert, James R.
Pollán, Marina
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Castaño-Vinyals, Gemma
Casabonne, Delphine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leucèmia limfocítica crònica
Càncer
Chronic lymphocytic leukemia
Cancer
topic Leucèmia limfocítica crònica
Càncer
Chronic lymphocytic leukemia
Cancer
description Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/148017
url https://hdl.handle.net/2445/148017
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu12010048
Nutrients, 2019, vol. 12, num. 1
https://doi.org/10.3390/nu12010048
dc.rights.none.fl_str_mv cc by (c) Flores et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Flores et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405457685151744
score 15,811543

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