Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study

We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) a...

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Bibliographic Details
Authors: Benavente, Yolanda, Costas, Laura, Rodríguez Suárez, Marta María, Alguacil, Juan, Santibáñez, Miguel, Vila, Javier, Robles, Claudia, Alonso Sanz, Esther, Banda, Esmeralda de la, González Barca, Eva, Dierssen Sotos, Trinidad, Gimeno Vázquez, Eva, Aymerich Gregorio, Marta, Campo Güerri, Elias, Jiménez Moleón, José Juan, Marcos Gragera, Rafael, Castaño-Vinyals, Gemma, Aragonès Sanz, Núria, Pollan, Marina, Sanjosé Llongueras, Silvia de, Kogevinas, Manolis, Tardón, Adonina, Casabonne, Delphine
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171743
Online Access:https://hdl.handle.net/2445/171743
Access Level:Open access
Keyword:Plaguicides
Leucèmia limfocítica crònica
Pesticides
Chronic lymphocytic leukemia
Description
Summary:We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010-2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.

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