The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study

Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish mult...

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Detalhes bibliográficos
Autores: Flores, José Carlos, Gracia Lavedan, Esther, Benavente, Yolanda, Amiano, Pilar, Romaguera, Dora, Costas, Laura, Robles, Claudia, González Barca, Eva, Banda, Esmeralda de la, Alonso Sanz, Esther, Aymerich Gregorio, Marta, Campo Güerri, Elias, Dierssen Sotos, Trinidad, Marcos Gragera, Rafael, Rodriguez Suarez, Marta María, Solans, Marta, Gimeno Vázquez, Eva, Garcia Martin, Paloma, Aragonès Sanz, Núria, Shivappa, Nitin, Hébert, James R., Pollán, Marina, Kogevinas, Manolis, Sanjosé Llongueras, Silvia de, Castaño-Vinyals, Gemma, Casabonne, Delphine
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/148017
Acesso em linha:https://hdl.handle.net/2445/148017
Access Level:Acceso aberto
Palavra-chave:Leucèmia limfocítica crònica
Càncer
Chronic lymphocytic leukemia
Cancer
Descrição
Resumo:Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.

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