From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities

Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothel...

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Autores: Hernáez, Álvaro, Jaramillo, Sara, Garcia-Borrego, Aránzazu, Espejo-Calvo, Juan Antonio, Covas, María Isabel, Blanchart, Gema, Fernández Prior, África, Fitó, Montserrat
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/151778
Acesso em linha:https://hdl.handle.net/11441/151778
https://doi.org/10.3390/antiox10020202
Access Level:acceso abierto
Palavra-chave:Olive tree
Phenolic compound
Triterpenes
Bioactivity
Functional olive oil
3,4-dihydroxyphenylglycol
Hydroxytyrosol
Oleuropein
Oleocanthal
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spelling From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary BioactivitiesHernáez, ÁlvaroJaramillo, SaraGarcia-Borrego, AránzazuEspejo-Calvo, Juan AntonioCovas, María IsabelBlanchart, GemaFernández Prior, ÁfricaFitó, MontserratOlive treePhenolic compoundTriterpenesBioactivityFunctional olive oil3,4-dihydroxyphenylglycolHydroxytyrosolOleuropeinOleocanthalOur aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0.05–0.5 μmol/L; Ts: 0.001–0.1 μmol/L) and nutraceutical doses (Ps: 1–10 μmol/L; Ts: 0.25–10 μmol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol (95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15 μmol/L; final nutraceutical concentration: 3 μmol/L) was the best in order to prepare functional products and nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among different olive components.MDPIBioquímica Médica y Biología Molecular e Inmunología2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/151778https://doi.org/10.3390/antiox10020202reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAntioxidants, 10 (2), 202.https://www.mdpi.com/2076-3921/10/2/202info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1517782026-06-17T12:51:07Z
dc.title.none.fl_str_mv From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
title From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
spellingShingle From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
Hernáez, Álvaro
Olive tree
Phenolic compound
Triterpenes
Bioactivity
Functional olive oil
3,4-dihydroxyphenylglycol
Hydroxytyrosol
Oleuropein
Oleocanthal
title_short From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
title_full From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
title_fullStr From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
title_full_unstemmed From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
title_sort From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities
dc.creator.none.fl_str_mv Hernáez, Álvaro
Jaramillo, Sara
Garcia-Borrego, Aránzazu
Espejo-Calvo, Juan Antonio
Covas, María Isabel
Blanchart, Gema
Fernández Prior, África
Fitó, Montserrat
author Hernáez, Álvaro
author_facet Hernáez, Álvaro
Jaramillo, Sara
Garcia-Borrego, Aránzazu
Espejo-Calvo, Juan Antonio
Covas, María Isabel
Blanchart, Gema
Fernández Prior, África
Fitó, Montserrat
author_role author
author2 Jaramillo, Sara
Garcia-Borrego, Aránzazu
Espejo-Calvo, Juan Antonio
Covas, María Isabel
Blanchart, Gema
Fernández Prior, África
Fitó, Montserrat
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Bioquímica Médica y Biología Molecular e Inmunología
dc.subject.none.fl_str_mv Olive tree
Phenolic compound
Triterpenes
Bioactivity
Functional olive oil
3,4-dihydroxyphenylglycol
Hydroxytyrosol
Oleuropein
Oleocanthal
topic Olive tree
Phenolic compound
Triterpenes
Bioactivity
Functional olive oil
3,4-dihydroxyphenylglycol
Hydroxytyrosol
Oleuropein
Oleocanthal
description Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0.05–0.5 μmol/L; Ts: 0.001–0.1 μmol/L) and nutraceutical doses (Ps: 1–10 μmol/L; Ts: 0.25–10 μmol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol (95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15 μmol/L; final nutraceutical concentration: 3 μmol/L) was the best in order to prepare functional products and nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among different olive components.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/151778
https://doi.org/10.3390/antiox10020202
url https://hdl.handle.net/11441/151778
https://doi.org/10.3390/antiox10020202
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antioxidants, 10 (2), 202.
https://www.mdpi.com/2076-3921/10/2/202
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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