Influence of the IL17A locus in giant cell arteritis susceptibility

Márquez, Ana; Hernández Rodríguez, José; Cid Xutglà, M. Cinta; Solans, Roser; Castañeda, Santos; Fernández-Contreras, M. E.; Ramentol, Marc; Morado, Inmaculada C.; Narváez García, Francisco Javier; Gómez Vaquero, Carmen; Martínez Taboada, Víctor Manuel; Ortego Centeno, Norberto; Sopeña, Bernardo; Monfort, Jordi; García-Villanueva, María Jesús; Caminal Montero, L.; Miguel, Eugenio de; Blanco, Ricardo; Spanish GCA Consortium; Palm, Oyvind; Molberg, O.; Latus, J.; Braun, Niko; Moosig, Frank; Witte, Torsten; Beretta, Lorenzo; Santaniello, Alessandro; Pazzola, Giulia; Boiardi, Luigi; Salvarani, Carlo; González-Gay, Miguel A.; Martín, Javier

Influence of the IL17A locus in giant cell arteritis susceptibility

Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a l...

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Autores:	Márquez, Ana, Hernández Rodríguez, José, Cid Xutglà, M. Cinta, Solans, Roser, Castañeda, Santos, Fernández-Contreras, M. E., Ramentol, Marc, Morado, Inmaculada C., Narváez García, Francisco Javier, Gómez Vaquero, Carmen, Martínez Taboada, Víctor Manuel, Ortego Centeno, Norberto, Sopeña, Bernardo, Monfort, Jordi, García-Villanueva, María Jesús, Caminal Montero, L., Miguel, Eugenio de, Blanco, Ricardo, Spanish GCA Consortium, Palm, Oyvind, Molberg, O., Latus, J., Braun, Niko, Moosig, Frank, Witte, Torsten, Beretta, Lorenzo, Santaniello, Alessandro, Pazzola, Giulia, Boiardi, Luigi, Salvarani, Carlo, González-Gay, Miguel A., Martín, Javier
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2014
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/112774
Acceso en línea:	https://hdl.handle.net/2445/112774
Access Level:	acceso abierto
Palabra clave:	Arteritis de cèl·lules gegants Genètica Polimorfisme genètic Metaanàlisi Giant cell arteritis Genetics Genetic polymorphisms Meta-analysis

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spelling	Influence of the IL17A locus in giant cell arteritis susceptibilityMárquez, AnaHernández Rodríguez, JoséCid Xutglà, M. CintaSolans, RoserCastañeda, SantosFernández-Contreras, M. E.Ramentol, MarcMorado, Inmaculada C.Narváez García, Francisco JavierGómez Vaquero, CarmenMartínez Taboada, Víctor ManuelOrtego Centeno, NorbertoSopeña, BernardoMonfort, JordiGarcía-Villanueva, María JesúsCaminal Montero, L.Miguel, Eugenio deBlanco, RicardoSpanish GCA ConsortiumPalm, OyvindMolberg, O.Latus, J.Braun, NikoMoosig, FrankWitte, TorstenBeretta, LorenzoSantaniello, AlessandroPazzola, GiuliaBoiardi, LuigiSalvarani, CarloGonzález-Gay, Miguel A.Martín, JavierArteritis de cèl·lules gegantsGenèticaPolimorfisme genèticMetaanàlisiGiant cell arteritisGeneticsGenetic polymorphismsMeta-analysisObjective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. Results: In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E−03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10−05). Conclusions: Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology.BMJ Publishing Group2017201720142017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/112774Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2014-205261Annals of the Rheumatic Diseases, 2014, vol. 73, num. 9, p. 1742-1745https://doi.org/10.1136/annrheumdis-2014-205261(c) BMJ Publishing Group, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1127742026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Influence of the IL17A locus in giant cell arteritis susceptibility
title	Influence of the IL17A locus in giant cell arteritis susceptibility
spellingShingle	Influence of the IL17A locus in giant cell arteritis susceptibility Márquez, Ana Arteritis de cèl·lules gegants Genètica Polimorfisme genètic Metaanàlisi Giant cell arteritis Genetics Genetic polymorphisms Meta-analysis
title_short	Influence of the IL17A locus in giant cell arteritis susceptibility
title_full	Influence of the IL17A locus in giant cell arteritis susceptibility
title_fullStr	Influence of the IL17A locus in giant cell arteritis susceptibility
title_full_unstemmed	Influence of the IL17A locus in giant cell arteritis susceptibility
title_sort	Influence of the IL17A locus in giant cell arteritis susceptibility
dc.creator.none.fl_str_mv	Márquez, Ana Hernández Rodríguez, José Cid Xutglà, M. Cinta Solans, Roser Castañeda, Santos Fernández-Contreras, M. E. Ramentol, Marc Morado, Inmaculada C. Narváez García, Francisco Javier Gómez Vaquero, Carmen Martínez Taboada, Víctor Manuel Ortego Centeno, Norberto Sopeña, Bernardo Monfort, Jordi García-Villanueva, María Jesús Caminal Montero, L. Miguel, Eugenio de Blanco, Ricardo Spanish GCA Consortium Palm, Oyvind Molberg, O. Latus, J. Braun, Niko Moosig, Frank Witte, Torsten Beretta, Lorenzo Santaniello, Alessandro Pazzola, Giulia Boiardi, Luigi Salvarani, Carlo González-Gay, Miguel A. Martín, Javier
author	Márquez, Ana
author_facet	Márquez, Ana Hernández Rodríguez, José Cid Xutglà, M. Cinta Solans, Roser Castañeda, Santos Fernández-Contreras, M. E. Ramentol, Marc Morado, Inmaculada C. Narváez García, Francisco Javier Gómez Vaquero, Carmen Martínez Taboada, Víctor Manuel Ortego Centeno, Norberto Sopeña, Bernardo Monfort, Jordi García-Villanueva, María Jesús Caminal Montero, L. Miguel, Eugenio de Blanco, Ricardo Spanish GCA Consortium Palm, Oyvind Molberg, O. Latus, J. Braun, Niko Moosig, Frank Witte, Torsten Beretta, Lorenzo Santaniello, Alessandro Pazzola, Giulia Boiardi, Luigi Salvarani, Carlo González-Gay, Miguel A. Martín, Javier
author_role	author
author2	Hernández Rodríguez, José Cid Xutglà, M. Cinta Solans, Roser Castañeda, Santos Fernández-Contreras, M. E. Ramentol, Marc Morado, Inmaculada C. Narváez García, Francisco Javier Gómez Vaquero, Carmen Martínez Taboada, Víctor Manuel Ortego Centeno, Norberto Sopeña, Bernardo Monfort, Jordi García-Villanueva, María Jesús Caminal Montero, L. Miguel, Eugenio de Blanco, Ricardo Spanish GCA Consortium Palm, Oyvind Molberg, O. Latus, J. Braun, Niko Moosig, Frank Witte, Torsten Beretta, Lorenzo Santaniello, Alessandro Pazzola, Giulia Boiardi, Luigi Salvarani, Carlo González-Gay, Miguel A. Martín, Javier
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Arteritis de cèl·lules gegants Genètica Polimorfisme genètic Metaanàlisi Giant cell arteritis Genetics Genetic polymorphisms Meta-analysis
topic	Arteritis de cèl·lules gegants Genètica Polimorfisme genètic Metaanàlisi Giant cell arteritis Genetics Genetic polymorphisms Meta-analysis
description	Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. Results: In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E−03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10−05). Conclusions: Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology.
publishDate	2014
dc.date.none.fl_str_mv	2014 2017 2017 2017
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/112774
url	https://hdl.handle.net/2445/112774
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2014-205261 Annals of the Rheumatic Diseases, 2014, vol. 73, num. 9, p. 1742-1745 https://doi.org/10.1136/annrheumdis-2014-205261
dc.rights.none.fl_str_mv	(c) BMJ Publishing Group, 2014 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) BMJ Publishing Group, 2014
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	4 p. application/pdf
dc.publisher.none.fl_str_mv	BMJ Publishing Group
publisher.none.fl_str_mv	BMJ Publishing Group
dc.source.none.fl_str_mv	Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Influence of the IL17A locus in giant cell arteritis susceptibility

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