Influence of the IL17A locus in giant cell arteritis susceptibility

Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a l...

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Detalles Bibliográficos
Autores: Márquez, Ana, Hernández Rodríguez, José, Cid Xutglà, M. Cinta, Solans, Roser, Castañeda, Santos, Fernández-Contreras, M. E., Ramentol, Marc, Morado, Inmaculada C., Narváez García, Francisco Javier, Gómez Vaquero, Carmen, Martínez Taboada, Víctor Manuel, Ortego Centeno, Norberto, Sopeña, Bernardo, Monfort, Jordi, García-Villanueva, María Jesús, Caminal Montero, L., Miguel, Eugenio de, Blanco, Ricardo, Spanish GCA Consortium, Palm, Oyvind, Molberg, O., Latus, J., Braun, Niko, Moosig, Frank, Witte, Torsten, Beretta, Lorenzo, Santaniello, Alessandro, Pazzola, Giulia, Boiardi, Luigi, Salvarani, Carlo, González-Gay, Miguel A., Martín, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/112774
Acceso en línea:https://hdl.handle.net/2445/112774
Access Level:acceso abierto
Palabra clave:Arteritis de cèl·lules gegants
Genètica
Polimorfisme genètic
Metaanàlisi
Giant cell arteritis
Genetics
Genetic polymorphisms
Meta-analysis
Descripción
Sumario:Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. Results: In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E−03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10−05). Conclusions: Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology.

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