Evidence of association of the NLRP1 gene with giant cell arteritis

Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required f...

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Detalhes bibliográficos
Autores: Serrano, Aurora, Carmona, F. David, Castañeda, Santos, Solans, Roser, Hernández Rodríguez, José, Cid Xutglà, M. Cinta, Prieto González, Sergio, Miranda-Filloy, José A., Rodríguez-Rodríguez, Luis, Morado, Inmaculada C., Gómez Vaquero, Carmen, Blanco, Ricardo, Sopeña, Bernardo, Ortego Centeno, Norberto, Unzurrunzaga, Ainhoa, Marí-Alfonso, Begoña, Sánchez-Martin, Julio, García-Villanueva, María Jesús, Hidalgo-Conde, Ana, Pazzola, Giulia, Boiardi, Luigi, Salvarani, Carlo, González-Gay, Miguel A., Martín, Javier
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/112543
Acesso em linha:https://hdl.handle.net/2445/112543
Access Level:Acceso aberto
Palavra-chave:Arteritis de cèl·lules gegants
Polimorfisme genètic
Genètica
Giant cell arteritis
Genetic polymorphisms
Genetics
Descrição
Resumo:Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation.

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