The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

Persistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and assess whether these...

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Detalles Bibliográficos
Autores: Garrido-Rodríguez, Vanesa, Bulnes-Ramos, Ángel, Olivas-Martínez, Israel, Pozo-Balado, Maria del Mar del, Álvarez-Ríos, Ana Isabel, Gutiérrez, Félix, Izquierdo, Rebeca, García, Federico, Tiraboschi, Juan Manuel, Vera-Méndez, Francisco, Peraire, Joaquim, Rull, Anna, Pacheco, Yolanda M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/386275
Acceso en línea:http://hdl.handle.net/10261/386275
https://api.elsevier.com/content/abstract/scopus_id/85202576975
Access Level:acceso abierto
Palabra clave:CD4/CD8 ratio
HIV-Infection
Immunological dysfunction
Nadir-CD4 T-cell
sj/β-TRECs
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spelling The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic functionGarrido-Rodríguez, VanesaBulnes-Ramos, ÁngelOlivas-Martínez, IsraelPozo-Balado, Maria del Mar delÁlvarez-Ríos, Ana IsabelGutiérrez, FélixIzquierdo, RebecaGarcía, FedericoTiraboschi, Juan ManuelVera-Méndez, FranciscoPeraire, JoaquimRull, AnnaPacheco, Yolanda M.CD4/CD8 ratioHIV-InfectionImmunological dysfunctionNadir-CD4 T-cellsj/β-TRECsPersistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and assess whether these features vary from those associated to a low nadir-CD4, another well-established predictor of disease progression.This work was supported by grants from the Fondo de Investigación Sanitaria [FIS; PI18/01216, PI20/00326 and PI21/00357] and the Ministerio de Ciencia, Innovación y Universidades [CNS2023/1444725] which are co-funded by Fondos Europeos para el Desarrollo Regional (FEDER) “A way to make Europe”; the Instituto de Salud Carlos III [FI19/00298 to V.G-R; CD19/00143 to A.B-R, CM19/00051 to I.O-M and CP19/00146 to A.R]; the Consejería de Transformación Económica, Industria, Conocimiento y Universidades [DOC_01646 to MM.P-B] and the Consejería de Salud y Familias of Junta de Andalucía through the “Nicolás Monardes” [RC-0006-2021 to YM.P]. The HIV BioBank is supported by Instituto de Salud Carlos III (PT20/00138) and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN (CB22/01/00041). CoRIS cohort are supported by CIBER - Consorcio Centro de Investigación Biomédica en Red- (CB21/13/00091), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU, A.R and J.P are also supported by CIBER-INF (CB21/13/00020). The funders had no role in the study design, data collection and interpretation, or the decision to submit the work for publication.Peer reviewedElsevier BVInstituto de Salud Carlos IIIEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Junta de AndalucíaCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)Garrido-Rodríguez, Vanesa [0000-0002-0031-1437]Álvarez-Ríos, Ana Isabel [0000-0003-2394-0890]Pacheco, Yolanda M. [0000-0002-9451-8083]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/386275https://api.elsevier.com/content/abstract/scopus_id/85202576975reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//CNS2023-1444725https://doi.org/10.1016/j.jmii.2024.08.007Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3862752026-05-22T06:33:51Z
dc.title.none.fl_str_mv The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
title The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
spellingShingle The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
Garrido-Rodríguez, Vanesa
CD4/CD8 ratio
HIV-Infection
Immunological dysfunction
Nadir-CD4 T-cell
sj/β-TRECs
title_short The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
title_full The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
title_fullStr The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
title_full_unstemmed The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
title_sort The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
dc.creator.none.fl_str_mv Garrido-Rodríguez, Vanesa
Bulnes-Ramos, Ángel
Olivas-Martínez, Israel
Pozo-Balado, Maria del Mar del
Álvarez-Ríos, Ana Isabel
Gutiérrez, Félix
Izquierdo, Rebeca
García, Federico
Tiraboschi, Juan Manuel
Vera-Méndez, Francisco
Peraire, Joaquim
Rull, Anna
Pacheco, Yolanda M.
author Garrido-Rodríguez, Vanesa
author_facet Garrido-Rodríguez, Vanesa
Bulnes-Ramos, Ángel
Olivas-Martínez, Israel
Pozo-Balado, Maria del Mar del
Álvarez-Ríos, Ana Isabel
Gutiérrez, Félix
Izquierdo, Rebeca
García, Federico
Tiraboschi, Juan Manuel
Vera-Méndez, Francisco
Peraire, Joaquim
Rull, Anna
Pacheco, Yolanda M.
author_role author
author2 Bulnes-Ramos, Ángel
Olivas-Martínez, Israel
Pozo-Balado, Maria del Mar del
Álvarez-Ríos, Ana Isabel
Gutiérrez, Félix
Izquierdo, Rebeca
García, Federico
Tiraboschi, Juan Manuel
Vera-Méndez, Francisco
Peraire, Joaquim
Rull, Anna
Pacheco, Yolanda M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
Junta de Andalucía
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)
Garrido-Rodríguez, Vanesa [0000-0002-0031-1437]
Álvarez-Ríos, Ana Isabel [0000-0003-2394-0890]
Pacheco, Yolanda M. [0000-0002-9451-8083]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CD4/CD8 ratio
HIV-Infection
Immunological dysfunction
Nadir-CD4 T-cell
sj/β-TRECs
topic CD4/CD8 ratio
HIV-Infection
Immunological dysfunction
Nadir-CD4 T-cell
sj/β-TRECs
description Persistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and assess whether these features vary from those associated to a low nadir-CD4, another well-established predictor of disease progression.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/386275
https://api.elsevier.com/content/abstract/scopus_id/85202576975
url http://hdl.handle.net/10261/386275
https://api.elsevier.com/content/abstract/scopus_id/85202576975
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//CNS2023-1444725
https://doi.org/10.1016/j.jmii.2024.08.007
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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