The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

Persistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and assess whether these...

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Detalles Bibliográficos
Autores: Garrido-Rodríguez, Vanesa, Bulnes-Ramos, Ángel, Olivas-Martínez, Israel, Pozo-Balado, Maria del Mar del, Álvarez-Ríos, Ana Isabel, Gutiérrez, Félix, Izquierdo, Rebeca, García, Federico, Tiraboschi, Juan Manuel, Vera-Méndez, Francisco, Peraire, Joaquim, Rull, Anna, Pacheco, Yolanda M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/386275
Acceso en línea:http://hdl.handle.net/10261/386275
https://api.elsevier.com/content/abstract/scopus_id/85202576975
Access Level:acceso abierto
Palabra clave:CD4/CD8 ratio
HIV-Infection
Immunological dysfunction
Nadir-CD4 T-cell
sj/β-TRECs
Descripción
Sumario:Persistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and assess whether these features vary from those associated to a low nadir-CD4, another well-established predictor of disease progression.

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