Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects

[Background] The persistence of an inverted CD4/CD8 ratio has been extensively associated with the increased morbimortality of chronic human immunodeficiency virus (HIV)-infected subjects. Thymic function is crucial for the maintenance of T cell homeostasis. We explored the impact of thymic function...

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Detalles Bibliográficos
Autores: Rosado-Sánchez, Isaac, Herrero-Fernández, Inés, Genebat, Miguel, Ruiz-Mateos, Ezequiel, Leal, Manuel, Pacheco, Yolanda M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/389460
Acceso en línea:http://hdl.handle.net/10261/389460
https://api.elsevier.com/content/abstract/scopus_id/85015190422
Access Level:acceso abierto
Palabra clave:Thymic function
CD4/CD8 ratio
HIV
Antiretroviral naive
Delta-TRECs
Descripción
Sumario:[Background] The persistence of an inverted CD4/CD8 ratio has been extensively associated with the increased morbimortality of chronic human immunodeficiency virus (HIV)-infected subjects. Thymic function is crucial for the maintenance of T cell homeostasis. We explored the impact of thymic function on the CD4/CD8 ratio of HIV-infected subjects.

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