Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential f...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/125270 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/125270 |
| Access Level: | acceso abierto |
| Palabra clave: | 612.82 Neurociencias (Biológicas) Fisiología animal (Biología) Biología celular (Biología) 2407.04 Citología 2411.11 Neurofisiología 2490 Neurociencias 3205.07 Neurología |
| Sumario: | The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies. |
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